Traditional Chinese medicine composition for promoting regeneration of hippocampal neurons
A hippocampal neuron and cell regeneration technology, which is applied in drug combinations, nervous system diseases, and pharmaceutical formulations, can solve problems such as reducing brain neurotrophic factors, and achieve the effect of promoting hippocampal neuron cell regeneration and treating depression
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Embodiment 1
[0047] The formula provided by the present invention: Acanthopanax 10g; Morinda officinalis 10g; Curcuma 10g; Polygala 3g; Baiziren 10g;
[0048] The preparation method is:
[0049] 1) Mix the above-mentioned Chinese medicine ingredients evenly, add cold water and soak for half an hour, and the amount of water soaks the medicine surface by 1.5-3 cm;
[0050] 2) Decocting for the first time: heating, boiling the medicinal liquid, decocting for 20 minutes, filtering, and separating the first decoction liquid and the first decoction dregs;
[0051] 3) The second decoction: add cold water to the first decoction residue for the second decoction, decoct for the second time after the second decoction liquid boils and then decoct for 15 minutes, separate the second decoction liquid and the second decoction residue;
[0052] 4) Mix the first decoction and the second decoction evenly.
[0053] The above-mentioned one dose of medicine can obtain 300-400mL, mix it and divide it into two...
Embodiment 2
[0054] Embodiment 2 pharmacodynamic experiment
[0055] 1 Materials and methods:
[0056] 1.1 Materials:
[0057] 1.1.1 Animals: SPF grade male SD rats, weighing 200g-210g, age: 7 weeks, 40 rats.
[0058] 1.2 Method:
[0059] 1.2.1 Grouping of animals: After one week of adaptive feeding, the rats were randomly divided into four groups, namely blank group, model group, positive control group and core prescription group, with 10 rats in each group.
[0060] 1.2.2 Animal modeling: Except for the blank group, all the other three groups were modeled. The model-making method was established according to the chronic reserpine-induced animal model, and the rats were intraperitoneally injected with reserpine injection 0.2 mg / kg every day for 21 consecutive days.
[0061] 1.2.3 Administration in groups: the blank group was not given any stimulation, and they drank water and diet normally, and the rats in the other groups were administered 30 minutes before intraperitoneal injection....
Embodiment 3
[0080] Embodiment 3 safety experiment
[0081] 1 Materials and methods:
[0082] 1.1 Materials:
[0083] 1.1.1 Animals: SPF grade SD rats, half male and half male, body weight 200g-210g, age: 7 weeks, 40 rats.
[0084] 1.2 Method:
[0085] 1.2.1 Grouping of animals: After one week of adaptive feeding, the rats were randomly divided into four groups, namely the control group, the core prescription low, medium and high dose groups, with 10 rats in each group
[0086] 1.2.2 Administration in groups: The core prescription low-dose group is given the core prescription water decoction by intragastric administration, the dosage is 1ml / 100g, and the administration concentration is 0.66g / ml (the concentration is the normal administration concentration, and the calculation method is the same as before. ). The middle dosage group of the core prescription was intragastrically administered the water decoction of the core prescription, the dosage was 1ml / 100g, and the concentration was ...
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Abstract
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