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Traditional Chinese medicine composition for promoting regeneration of hippocampal neurons

A hippocampal neuron and cell regeneration technology, which is applied in drug combinations, nervous system diseases, and pharmaceutical formulations, can solve problems such as reducing brain neurotrophic factors, and achieve the effect of promoting hippocampal neuron cell regeneration and treating depression

Active Publication Date: 2019-05-03
何原
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3. Stress also reduces brain neurotrophic factors, such as BDNF, NGF, VEGF and NT-1, etc.

Method used

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  • Traditional Chinese medicine composition for promoting regeneration of hippocampal neurons
  • Traditional Chinese medicine composition for promoting regeneration of hippocampal neurons
  • Traditional Chinese medicine composition for promoting regeneration of hippocampal neurons

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The formula provided by the present invention: Acanthopanax 10g; Morinda officinalis 10g; Curcuma 10g; Polygala 3g; Baiziren 10g;

[0048] The preparation method is:

[0049] 1) Mix the above-mentioned Chinese medicine ingredients evenly, add cold water and soak for half an hour, and the amount of water soaks the medicine surface by 1.5-3 cm;

[0050] 2) Decocting for the first time: heating, boiling the medicinal liquid, decocting for 20 minutes, filtering, and separating the first decoction liquid and the first decoction dregs;

[0051] 3) The second decoction: add cold water to the first decoction residue for the second decoction, decoct for the second time after the second decoction liquid boils and then decoct for 15 minutes, separate the second decoction liquid and the second decoction residue;

[0052] 4) Mix the first decoction and the second decoction evenly.

[0053] The above-mentioned one dose of medicine can obtain 300-400mL, mix it and divide it into two...

Embodiment 2

[0054] Embodiment 2 pharmacodynamic experiment

[0055] 1 Materials and methods:

[0056] 1.1 Materials:

[0057] 1.1.1 Animals: SPF grade male SD rats, weighing 200g-210g, age: 7 weeks, 40 rats.

[0058] 1.2 Method:

[0059] 1.2.1 Grouping of animals: After one week of adaptive feeding, the rats were randomly divided into four groups, namely blank group, model group, positive control group and core prescription group, with 10 rats in each group.

[0060] 1.2.2 Animal modeling: Except for the blank group, all the other three groups were modeled. The model-making method was established according to the chronic reserpine-induced animal model, and the rats were intraperitoneally injected with reserpine injection 0.2 mg / kg every day for 21 consecutive days.

[0061] 1.2.3 Administration in groups: the blank group was not given any stimulation, and they drank water and diet normally, and the rats in the other groups were administered 30 minutes before intraperitoneal injection....

Embodiment 3

[0080] Embodiment 3 safety experiment

[0081] 1 Materials and methods:

[0082] 1.1 Materials:

[0083] 1.1.1 Animals: SPF grade SD rats, half male and half male, body weight 200g-210g, age: 7 weeks, 40 rats.

[0084] 1.2 Method:

[0085] 1.2.1 Grouping of animals: After one week of adaptive feeding, the rats were randomly divided into four groups, namely the control group, the core prescription low, medium and high dose groups, with 10 rats in each group

[0086] 1.2.2 Administration in groups: The core prescription low-dose group is given the core prescription water decoction by intragastric administration, the dosage is 1ml / 100g, and the administration concentration is 0.66g / ml (the concentration is the normal administration concentration, and the calculation method is the same as before. ). The middle dosage group of the core prescription was intragastrically administered the water decoction of the core prescription, the dosage was 1ml / 100g, and the concentration was ...

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Abstract

The invention provides a traditional Chinese medicine composition for promoting regeneration of hippocampal neurons. The composition is prepared from the following components in parts by weight: 5-20parts of acanthopanax roots, 5-20 parts of medicinal Indian mulberry roots, 5-20 parts of turmeric root tuber, 1-15 parts of polygala roots, 5-20 parts of platycladi seeds, 3-15 parts of Chinese magnoliavine fruits, 5-20 parts of nutgrass galingale rhizome, 1-10 parts of lotus plumules, 3-15 parts of prepared pinellia tubers and 1-10 parts of pseudo-ginseng. The traditional Chinese medicine composition can be used for promoting regeneration of hippocampal neurons and regulating 5-HT1AR mediated CAMP-CREB-BDNF channel so as to achieve the effect of treating depression.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition which can promote the regeneration of hippocampal neuron cells, in particular to a traditional Chinese medicine composition which can promote the regeneration of hippocampal neuron cells. Background technique [0002] Proliferative neural progenitor / neural stem cells can, under the right circumstances, generate new neurons and integrate them into existing neuronal circuits, a process known as neurogenesis. Studies have confirmed that there are two neural stem cell accumulation areas in the central nervous system of adult mammals: the subventricular zone (SVZ) of the lateral ventricle wall and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus (Johansson CB, Momma S , Clarke DL, etal. Identification of a neural stem cell in the adult mammalian centralnervoussystem. Cell, 1999, 96:25-34. Gage FH. Mammalian neurol ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P25/24
Inventor 高蕊
Owner 何原
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