Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug for preventing and treating ischemic heart diseases, and application thereof

A technology of ischemic heart disease and drugs, applied in the direction of blood diseases, drug combinations, cardiovascular system diseases, etc., can solve the problems such as the death risk of patients with coronary heart disease that have not yet been seen, and achieve the improvement of myocardial cell damage, increase ROS, and inhibit lipids. The effect of mass peroxidation

Inactive Publication Date: 2019-04-26
BMK BIOMEDICAL TECH GUANGZHOU CO LTD +1
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there has been no report on the use of indolepropionic acid and its derivatives to treat ischemic heart disease and reduce the risk of death in patients with coronary heart disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug for preventing and treating ischemic heart diseases, and application thereof
  • Drug for preventing and treating ischemic heart diseases, and application thereof
  • Drug for preventing and treating ischemic heart diseases, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment provides a medicine for preventing and treating ischemic heart disease, which includes indole propionic acid, and the structural formula of indole propionic acid is as follows:

[0036]

Embodiment 2

[0038] This embodiment provides a drug for preventing and treating ischemic heart disease, which includes indole propionic acid and its derivatives, wherein the structural formula of the indole propionic acid derivatives is as follows:

[0039]

[0040] In this structural formula, R1 is phenyl, and R2, R4, R5, R6 and R7 are all hydrogen.

Embodiment 3

[0042] This embodiment provides a drug for preventing and treating ischemic heart disease, which includes indole propionic acid and its derivatives, wherein the structural formula of the indole propionic acid derivatives is as follows:

[0043]

[0044] In this structural formula, R5 is a hydroxyl group, and R1, R2, R4, R6 and R7 are all hydrogen.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a drug for preventing and treating ischemic heart diseases, and application thereof, and belongs to the field of pharmacy. The drug has the advantages that in-vivo and in-vitrostudies prove that indolepropionic acid (IPA) can increase the survival rate of myocardial cells injured by ischemia and hypoxia, inhibit reactive oxygen-induced lipid peroxidation, reduce oxidativestress, obviously improve the ROS (reactive oxygen species) value and superoxide dismutase activity of the ischemic and anoxic myocardial cells and relieve myocardial cell injuries, and has a protection effect on the ischemic and anoxic myocardial cells, thereby effectively improving the cardiac function and survival rate of patients with coronary heart disease. The drug containing the indolepropionic acid and derivatives thereof can serve as a therapeutic drug that is applied to treating the ischemic heart disease and reducing the mortality risk of the patients with the coronary heart disease, is used for treating the myocardial injury heart disease caused by hypertension, diabetes, thrombotic diseases, etc., and has a very good application prospect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a medicine for preventing and treating ischemic heart disease and its application. Background technique [0002] In recent years, with the development of society and economy, changes in eating habits and environment, the intensification of the pace of life and the acceleration of the aging process of the population, the prevalence and mortality of cardiovascular diseases in my country are still on the rise. The number of people suffering from cardiovascular diseases is 290 million, and the mortality rate of cardiovascular diseases ranks first, higher than that of tumors and other diseases, accounting for more than 40% of the residents' disease deaths. According to the "China Cardiovascular Disease Report 2016", the number of patients with coronary heart disease in my country has reached 11 million. Although the primary and secondary prevention measures for coronary heart disease are bein...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61P9/10A61P9/12A61P3/10A61P7/02A61P9/00
CPCA61K31/405A61P3/10A61P7/02A61P9/00A61P9/10A61P9/12
Inventor 钟诗龙朱茜王子贤刘仪滨马红坤秦敏汤雅男
Owner BMK BIOMEDICAL TECH GUANGZHOU CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com