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Cell sorting device

A sorting device and cell technology, applied in the field of cell screening, can solve the problems of fragile cells, complicated operation, and low throughput

Inactive Publication Date: 2019-04-19
INST OF MICROELECTRONICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a cell sorting device to solve the problems of low throughput, complicated operation and easy damage of cells in the prior art

Method used

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  • Cell sorting device
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Examples

Experimental program
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Embodiment 1

[0048] Embodiment 1 and Embodiment 2 both use the channel itself to disturb the fluid, and can realize the integration of separation and anti-clogging without external devices, which saves the production cost of the device.

[0049] like Figure 5 and Image 6 As shown, Embodiment 3 of the present invention provides a cell sorting device. In this embodiment, the housing 10 is a tubular structure with a closed bottom, and part of the side walls of the housing 10 are inclined, and the inclined side walls The housing 10 is gradually inclined outward from the top to the bottom, and the first outlet 13 is disposed on the inclined side wall. By arranging the first outlet 13 on the inclined side wall, due to the effect of gravity G, larger cells will slide down due to the influence of the inclined surface, and will not adhere to the surface of the chip due to centrifugal force, and more effectively inhibit the cell sieve Blockage and boost flux.

[0050] In this embodiment, the ce...

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PUM

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Abstract

The invention provides a cell sorting device. The cell sorting device comprises a shell and a screening chip; the shell is internally provided with an inlet, a fluid passage and a first outlet, and the inlet and the first outlet are communicated with the fluid passage separately; the screening chip is arranged at the first outlet and comprises a screening area and a packaging area, the packaging area is located at the outer side of the screening area and used for being connected with the shell, a plurality of through holes are formed in the screening area, the screening area is made of a silicon material, and the thickness of the screening area is less than 25 micrometers. By means of the technical scheme, the problems of low throughput, complicated operation and easy breakage of cells inthe prior art can be solved.

Description

technical field [0001] The invention relates to the technical field of cell screening, in particular to a cell sorting device. Background technique [0002] At present, the usual cell isolation and screening methods can be divided into two categories, namely labeling methods and non-labeling methods. The labeling method refers to marking on cell antibodies, using the binding specificity of antibodies to specific antigens as a method for screening cells. Currently, flow cytometry and immunomagnetic beads are the two most common marker screening methods. The non-marking method refers to the use of the physical properties of cells (such as cell size, movement, hydrophilicity, electrical properties, etc.) to classify, such as through image processing to distinguish cell types of different sizes and volumes; through the movement characteristics of cells in laminar flow Sorting by different methods; specificity of cell impedance under high-frequency alternating current and separ...

Claims

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Application Information

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IPC IPC(8): C12M1/42C12M1/02C12M1/00
CPCC12M23/16C12M27/02C12M35/04C12M35/06
Inventor 黄成军赵阳程洁
Owner INST OF MICROELECTRONICS CHINESE ACAD OF SCI
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