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Preparation method of radix bupleuri or vinegar-baked bupleurum root formula granules

A technology of formula granules and Vinegar Bupleurum, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems such as low dissolution and transfer rate of saikosaponin, easy destruction of active ingredients, etc., to improve product quality. quality, reducing the effect of chemical degradation

Pending Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to overcome the above-mentioned problems in the prior art that the dissolution and transfer rate of saikosaponin is low, and the active ingredients extracted at high temperature are easily destroyed, the object of the present invention is to provide a method for preparing Bupleurum or vinegar Bupleurum formula granules. The method adopts continuous countercurrent Extraction, high-temperature short-term sterilization, vacuum concentration, instantaneous spray drying and dry granulation production processes enable the content of saikosaponin a and saikosaponin d in Bupleurum bupleuri or vinegar bupleurum formula granules to reach a higher level continuously and stably , to ensure that the transfer rate of active ingredients in Bupleurum or Vinegar Bupleurum Formula Granules meets the technical requirements of Bupleurum Standard Decoction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of Bupleurum formula granules, comprising the steps of:

[0041] a. Select the Radix Bupleurum medicinal material, vibrate and sieve it to remove impurities, and crush it into 0.2cm particles;

[0042] b. Wet the crushed coarse particles with 2 times the amount of water, input them into the spiral continuous dynamic countercurrent extractor, reversely add 10 times the amount of hot water at 90°C for continuous countercurrent extraction for 0.5h, collect the extract, and extract the Bupleuri herb The slag is extruded to recover part of the medicinal solution and then discharged, and the recovered part of the medicinal solution is combined with the extract; the input speed of the crushed coarse particles is 100kg / h, and the flow rate of reversely added hot water is 1000L / h;

[0043] c. The combined extracts are cooled to 50°C and then filtered. The filtrate is sterilized in an ultra-high temperature instantaneous sterilizer (UHT) at 105°C for 20 secon...

Embodiment 2

[0047] A preparation method of Bupleurum formula granules, comprising the steps of:

[0048] a. Select the Radix Bupleurum medicinal material, vibrate and sieve it to remove impurities, and crush it into 0.2cm particles;

[0049] b. Wet the crushed coarse particles with 2 times the amount of water, input them into the spiral continuous dynamic countercurrent extractor, reversely add 10 times the amount of hot water at 90°C for continuous countercurrent extraction for 0.5h, collect the extract, and extract the Bupleuri herb The slag is extruded to recover part of the medicinal solution and then discharged, and the recovered part of the medicinal solution is combined with the extract; the input speed of the crushed coarse particles is 100kg / h, and the flow rate of reversely added hot water is 1000L / h;

[0050] c. The combined extracts are filtered, and the filtrate is sterilized in an ultra-high temperature instantaneous sterilizer (UHT) at 105°C for 20 seconds, and then concent...

Embodiment 3

[0054] A preparation method of Bupleurum formula granules, comprising the steps of:

[0055] a. Select the Radix Bupleurum medicinal material, vibrate and sieve it to remove impurities, and crush it into 0.2cm particles;

[0056] b. Input the crushed coarse particles into the spiral continuous dynamic countercurrent extractor, reversely add 10 times the amount of 90°C hot water for continuous countercurrent extraction for 0.5h, collect the extract, and discharge the Bupleurum dregs; the crushed The input speed of coarse particles is 100kg / h, and the flow rate of reversely adding hot water is 1000L / h;

[0057] c. The combined extracts are cooled to 50°C and then filtered. The filtrate is sterilized in an ultra-high temperature instantaneous sterilizer (UHT) at 105°C for 20 seconds, and then concentrated under reduced pressure at 50°C to obtain a clear liquid with a relative density of 1.10. paste;

[0058] d. Take the clear paste and add β-cyclodextrin to dissolve and stir ev...

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Abstract

The invention discloses a preparation method of radix bupleuri or vinegar-baked bupleurum root formula granules. The preparation method comprises the steps that a, radix bupleuri or vinegar-baked bupleurum root is crushed into coarse particles; b, the coarse particles are continuously input into a continuous dynamic countercurrent extraction machine, hot water is reversely added for continuous dynamic countercurrent extraction, and an extracting solution is collected; c, the extracting solution is filtered and subjected to high temperature sterilization, and filtrate is concentrated under reduced pressure to form a clear paste; d, excipients are added to the clear paste for dissolution, and spray drying is performed to obtain dry extract powder; and e, preparation excipients are added to the dry extract powder, and dry granulation is performed to obtain the radix bupleuri or vinegar-baked bupleurum root formula granules. The preparation method adopts a production process of continuouscountercurrent extraction, high temperature instantaneous sterilization, pressure-reduced concentration, spray drying and dry granulation, and researches various process parameters, so that the content of saikosaponin a and saikosaponin-d in the radix bupleuri or vinegar-baked bupleurum root formula granules can be continuously and stably maintained to achieve a higher level, it is ensured that the active ingredient transfer rate is consistent with the radix bupleuri standard decoction, and the product quality of the radix bupleuri or vinegar-baked bupleurum root formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Bupleurum bupleuri or vinegar bupleurum formula granules. Background technique [0002] Traditional Chinese medicine formula granules are made by extracting, concentrating, drying, and granulating single-flavored Chinese medicine decoction pieces. Among them, Bupleurum and Vinegar Bupleurum formula granules are one of the two most commonly used traditional Chinese medicine formula granules in clinical practice. [0003] Bupleurum bupleuri Bupleurum chinense DC. or Bupleurum angustifolia Bupleurum scorzonerifolium The dry root of Willd., recorded in the 2015 edition of the "Chinese Pharmacopoeia", has the functions of evacuating and reducing fever, soothing the liver and relieving stagnation, and promoting Yang Qi. Uterine prolapse, prolapse of the anus, etc., are commonly used Chinese medicine decoct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/233A61K9/16
CPCA61K9/1652A61K9/1682A61K36/233A61K2236/331A61K2236/51
Inventor 刘燎原曾昭君方朝缵张正干丽张志鹏蔡盛康
Owner GUANGDONG YIFANG PHARMA
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