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Chemical ionization source based on novel reagent ions and self-calibration

A chemical ionization source and molecular ionization technology, applied in the field of ionization sources, can solve problems such as pollution and instrument instability, achieve the effects of improving ionization efficiency, improving collision paths, and solving instrument instability

Pending Publication Date: 2019-03-29
FOCUSED PHOTONICS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to overcome at least one defect of the existing chemical ionization source, and provides a chemical ionization source based on a new type of reagent ion and self-calibration, which solves the problem caused by the contamination of the VUV light window by separating the reagent ion generation area and the sample molecule ionization area. Instrument instability problem

Method used

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  • Chemical ionization source based on novel reagent ions and self-calibration
  • Chemical ionization source based on novel reagent ions and self-calibration
  • Chemical ionization source based on novel reagent ions and self-calibration

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Embodiment 1

[0037] The chemical ionization source of the present invention is based on a novel reagent ion and a self-calibrating chemical ionization source for ionizing sample molecules to generate sample ions suitable for mass spectrometry analysis.

[0038] figure 1 is a schematic structural diagram of a chemical ionization source according to an embodiment of the present invention. Such as figure 1 As shown, the embodiment of the present invention provides a chemical ionization source, which includes a light source 10 and an ionization chamber 20 . Wherein, the ionization chamber 20 includes: a reagent ion generation area 21 , a sample molecule ionization area 22 and a light-shielding hole electrode 23 arranged between the reagent ion generation area 21 and the sample molecule ionization area 22 .

[0039] The reagent ion generation area 21 is arranged on the side of the ionization chamber 20 close to the light source 10, and coaxial multi-sheet electrodes are arranged in it; The r...

Embodiment 2

[0047] figure 2 It is a schematic structural diagram of a chemical ionization source according to this embodiment. The chemical ionization source of embodiment 2 is improved on the basis of embodiment 1, and its difference lies in: through feedback adjustment, the concentration of reagent molecules is controlled, so that the generated The concentration of reagent ions is kept constant.

[0048] Specifically, such as figure 2 As shown, the reagent gas generating chamber 50 includes a dynamic calibrator 501, a high-concentration reagent molecular standard gas chamber 51, a high-purity nitrogen gas chamber 52, a reagent gas speed regulating valve 53, and a nitrogen gas speed regulating valve 54; the high-concentration reagent molecular standard gas chamber 51 One inlet of the dynamic calibrator 501 is connected via a reagent gas speed regulating valve 53 , and the high-purity nitrogen chamber 52 is connected to the other inlet of the dynamic calibrator 501 via a nitrogen speed...

Embodiment 3

[0052] image 3 It is a schematic structural diagram of a chemical ionization source according to this embodiment. The chemical ionization source of embodiment 3 is improved on the basis of embodiment 1. The difference is that the chemical ionization source also includes a radio frequency voltage generator, The radio frequency voltage generator connects multiple electrodes in the sample molecule ionization region 22 and applies a radio frequency electric field to the sample molecule ionization region 22 .

[0053] Further, the multiple electrodes in the sample molecule ionization region 22 include a positive ionization electrode located on one side of the irradiation path of the light source 10 and a negative ionization electrode located on the other side of the irradiation path of the light source 10 . The first pole (RF+) of the radio frequency voltage generator is connected to the positive ionization electrode, and the second pole (RF-) of the radio frequency voltage genera...

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Abstract

The invention provides a chemical ionization source based on novel reagent ions and self-calibration. The chemical ionization source is used for ionization of sample molecules, and includes a light source and an ionization cavity, wherein the ionization cavity includes a reagent ion generation region, a sample molecule ionization region, and a shading pore electrode which is arranged between the reagent ion generation region and the sample molecule ionization region; the reagent ion generation region is used for generating reagent ions for the reagent ions, and the reagent ions enter the sample molecule ionization region by passing through the shading pore electrode, and the reagent ions and the sample molecules generate ion molecule reaction, so as to enable the sample molecules to be ionized into sample ions for mass-spectrometer measurement, and then the sample ions enter an external mass spectrometer through a sample ion outlet; and through the separated reagent ion generation region and sample molecule ionization region, the chemical ionization source based on novel reagent ions and self-calibration solves the problem that the instrument is not stable because of pollution of aVUV light window.

Description

technical field [0001] The invention relates to an ionization source, in particular to a chemical ionization source based on novel reagent ions and self-calibration. Background technique [0002] The single photon ionization source is a common ionization source used in mass spectrometry, and its ion source is usually a vacuum ultraviolet lamp (VUV lamp). The single photon ionization source applies threshold ionization technology, that is, the ionization energy of the compound is lower than the energy of the photon to be ionized and detected. At present, there are the following problems: [0003] (1) The photons generated by the VUV lamp interfere with the ionization of the sample molecules, and the VUV light window is easily polluted, which leads to the attenuation of the detection sensitivity and the instability of the instrument; [0004] (2) In the single photon ionization source, the ionization efficiency of the compound close to the electron energy of the VUV light is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/14
CPCH01J49/145
Inventor 刘巍
Owner FOCUSED PHOTONICS
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