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Vaccine transdermal delivery device based on acoustically induced micro-pore arrays

A technology of microhole array and delivery device, which is applied in the direction of microneedles, drug devices, hypodermic injection devices, etc., and can solve the problems of high cost, complicated process, and poor accuracy of delivery area

Active Publication Date: 2019-03-26
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a vaccine transdermal delivery device based on an acoustically induced micropore array to solve the problems of inability to deliver macromolecular vaccine antigens, painful delivery process, complicated process and high cost in the existing technology of percutaneous administration for immunization. Problems such as poor delivery area accuracy

Method used

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  • Vaccine transdermal delivery device based on acoustically induced micro-pore arrays
  • Vaccine transdermal delivery device based on acoustically induced micro-pore arrays
  • Vaccine transdermal delivery device based on acoustically induced micro-pore arrays

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Embodiment 1

[0038] Example 1: please refer to Figure 1-3 , this embodiment discloses a vaccine transdermal delivery device 1 based on an acoustically induced microwell array, which includes: a main control system 11 connected to the main control system 11 The high-frequency intense focused ultrasound excitation component 12, and the sound-permeable immune patch 13 for applying to the skin for drug administration; the high-frequency strong focused ultrasound excitation component 12 includes a high-frequency ultrasonic signal generation system 121, and the high-frequency The first ultrasonic transducer 122 connected to the high-frequency ultrasonic signal generation system 121, the conical coupling catheter 123 connected with the first ultrasonic transducer 122; the conical coupling catheter 123 is placed in the acoustic On the permeable immune patch 13, it is used to conduct the acoustic energy of the first ultrasonic transducer 122 to the immune patch; the high-frequency ultrasonic signa...

Embodiment 2

[0052] Example 2: Reference Figure 4-5 , based on the above-mentioned embodiments, this embodiment provides a vaccine transdermal delivery device 1 based on an acoustically induced microwell array, wherein,

[0053] The first ultrasonic transducer 122 is an annular hollow first ultrasonic transducer 122 ; an accommodating cavity 122a is provided in the annular hollow area.

[0054] Further, the vaccine transdermal delivery device 1 based on the sound-induced microwell array also includes an ultrasonic echo signal monitoring system 14 connected to the main control system 11;

[0055] The ultrasonic echo signal monitoring system 14 includes a second ultrasonic transducer 141 and a signal monitoring assembly 142 electrically connected to each other; the outer diameter of the second ultrasonic transducer 141 is not larger than the accommodating cavity 122a The inner diameter of is used to be placed in the accommodating cavity 122a during monitoring;

[0056] The echo signal mon...

Embodiment 3

[0068] Example 3: Reference Figure 6-7 , based on the above-mentioned embodiment 2, this embodiment provides a vaccine transdermal delivery device 1 based on an acoustically induced microwell array, and the vaccine transdermal delivery device 1 based on an acoustically induced microwell array also includes the main control system 11 connected optical imaging monitoring system 15;

[0069] The optical imaging monitoring system includes an imaging probe 151, and an imaging processing unit 152 connected to the imaging probe 151;

[0070] The outer diameter of the imaging probe 151 is not greater than the inner diameter of the accommodating cavity 122a, and is used to be placed in the accommodating cavity 122a during monitoring;

[0071] The main control system 11 is also used to control the imaging probe 151 to collect images of the sound-permeable immune patch and / or skin, perform real-time or timing imaging, and process the imaging data through the imaging processing unit 152...

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Abstract

The invention provides a vaccine transdermal delivery device based on acoustically induced micro-pore arrays. The device comprises a master control system, a high-frequency strong focusing ultrasonicexcitation assembly and a sound-permeable immunization patch; the high-frequency strong focusing ultrasonic excitation assembly comprises a high-frequency ultrasonic signal generating system, a firstultrasonic transducer connected with the high-frequency ultrasonic signal generating system, and a conical coupling conduit connected with the first ultrasonic transducer; and the conical coupling conduit is arranged on the sound-permeable immunization patch during administration, and the front end of the conduit outputs high-frequency strong focusing ultrasonic energy to induce skins to form micro-pores and the micro-pore arrays. The position, the size and the depth of the acoustically induced micro-pores are precise and controllable, and the number of the acoustically induced micro-pores canbe designed and optimized by array combination, so fully-automatic vaccine transdermal immunization is achieved.

Description

technical field [0001] The invention belongs to the technical field of transdermal administration of immunization, in particular to a vaccine transdermal delivery device based on an acoustically induced micropore array. Background technique [0002] As the importance of the skin in the immune protection of the human body is gradually revealed, the concept of "skin immunity" has been established. The skin is the first line of defense for the human body against harmful substances in the external environment. There are many immune cells in the superficial skin including the epidermis and dermis, such as dendritic Langerhans cells and dermal dendritic cells. On the one hand, Langerhans cells control the formation of keratin, and on the other hand, they participate in the skin immune response. They are the main antigen-presenting cells in the skin epidermis. Usually the epidermis of the skin is about 100 microns thick. If the antigen can reach the epidermis, it can activate the ...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0061A61M2205/058
Inventor 胡亚欣杨梅陈昕
Owner SHENZHEN UNIV
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