Production process of tinidazole injection

Abstract

The invention provides a production process of a tinidazole injection. The production process comprises liquid preparation, filling and sterilizing. The production process specifically comprises the following steps: firstly, adding water for injection in a concentrating tank; fully dissolving tinidazole and adding the tinidazole into the concentrating tank to be uniformly mixed; then adding activated carbon to stir and adsorb; then adding sodium chloride to prepare a concentrated solution; decarbonizing the concentrated solution and importing the same into a diluted concentrating tank and adding the water for injection to total amount and uniformly mixing the solution to obtain the injection; and finally, filling and sterilizing the injection to obtain a finished product. The tinidazole isdissolved better. The production process can prevent heat source matters from entering the finished product more effectively.

Description

technical field [0001] The invention relates to a production process of medical tinidazole injection. Background technique [0002] Tinidazole injection is used to prevent postoperative anaerobic infection, especially suitable for anaerobic infection of gastrointestinal tract and female reproductive system. [0003] Tinidazole injection is prepared by mixing tinidazole raw material and sodium chloride, wherein the tinidazole raw material is white or light yellow powdery crystal. [0004] Existing tinidazole injection preparation process is as follows: [0005] 1. Weigh tinidazole and sodium chloride according to the prescription amount and put them into the concentrated preparation tank, use 60% of the full prescription water for injection, heat and stir to dissolve evenly, add 0.2% (W / V) activated carbon, make it fully stir evenly , keep warm (about 80°C) and adsorb for 10 minutes, filter and decarburize while hot and pressurized, and pour it into a dilute pot to obtain a...

AI Technical Summary

Problems solved by technology

[0012] Through the above two methods of blade stirring or reflux stirring, it is necessary to use another device to be placed in the tank and perform mechanical movement. During the mechanical movement, due to mechanical wear, a large amount of debris will be generated, and the debris will be mixed into the tank. In the liquid medicine, new pyrogenic substances will be formed, which are the unqualified factors of the injection, and the pyrogenic substances will cause the injection to cause discomfort in the patient.

Images