Anti-bacterial spray based on nano material and preparation method and application thereof

A technology of nanomaterials and sprays, applied in medical science, bandages, etc., can solve problems such as antibiotic abuse, achieve the effects of reducing recovery time, promoting skin growth, and good antibacterial effect

Active Publication Date: 2019-03-12
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The obtained antibacterial spray can solve the problem of antibiotic abuse in the field of antibacterial and anti-inflammation, which not only isolates but also replenishes and locks water

Method used

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  • Anti-bacterial spray based on nano material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 A kind of antibacterial spray based on nanometer material

[0028] The present embodiment provides a kind of antibacterial spray based on nanometer material, is made by the component of following parts by weight: liquid metal (GaIn 24.5 , the mass ratio of metal gallium to metal indium is 75.5:24.5) 3 parts, macromolecule organic material (polyethylene glycol, molecular weight 2000) 100 parts, chitosan 30 parts, water 3 parts.

[0029] The antibacterial spray obtained in Example 1 and the existing liquid metal-containing antibacterial dressing were carried out in an antibacterial comparative experiment, and the results showed that the antibacterial effect of the antibacterial spray of the present invention was significantly better than that of the existing antibacterial adjuvant.

Embodiment 2

[0030] Embodiment 2 A kind of preparation method of antibacterial spray

[0031] The preparation of antibacterial spray described in embodiment 1 comprises:

[0032] (1) Preparation of liquid metal micro-nano solution: Add 0.6 mg of liquid metal and 20 mg of macromolecular organic material polyethylene glycol to 20 ml of water, ultrasonicate, centrifuge to remove large particles, and remove water from the centrifuge to obtain liquid metal micro-nano in the form of microns or nanometers. Nanoparticles: Dissolving liquid metal micro-nanoparticles in a physiological solution and resuspending to obtain a liquid metal micro-nano solution, wherein the concentration of liquid metal is 1 mg / mL;

[0033] (2) Prepare chitosan nano solution: add 3g chitosan to 100ml 2% (mass fraction) glacial acetic acid solution and dissolve, then add 3% (mass fraction) hydrogen peroxide in right amount, after the reaction, add 10% (mass fraction) 1ml of sodium tripolyphosphate solution was used to con...

Embodiment 3

[0035] Embodiment 3 A kind of skin wound treatment method

[0036] A method for treating skin wounds, comprising: first using the antibacterial spray obtained in Example 1 to treat the wound, then applying the hydrogel colloid to the affected part of the wound to achieve the effect of replenishing water and moisturizing, and finally covering the hydrogel dressing to achieve the effect of rehydration. The role of the isolation package.

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Abstract

The invention relates to an anti-bacterial spray based on a nano material and a preparation method and application thereof. Active ingredients of the anti-bacterial spray comprise liquid metal and chitosan, wherein a mass ratio thereof is 1:(10 to 20). The anti-bacterial spray has the double anti-bacterial effects, and is more conveniently used medically or domestically. The invention further provides an anti-bacterial spray system. The anti-bacterial spray system uses hydrogel as a drug sustained release layer, is capable of guaranteeing water replenishing and moisture preserving, further promoting skin growth, accelerating wound healing, greatly improving the anti-bacterial effect, and reducing recovery time, and has the good anti-bacterial effect on various wounds of a knife wound, scald and the like.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to an antibacterial spray based on nanomaterials and a preparation method thereof. Background technique [0002] After long-term exploration, people have found that a moist environment is very important for wound healing, while traditional external dressings such as band-aids, gauze, and cotton cloth can only achieve the effect of isolation, but cannot meet the requirements of moisturizing and locking. [0003] Existing literature has disclosed that liquid metal can be used as an antibacterial material combined with plant antibacterial material, which can be used in medical non-woven dressings. However, it exists in the form of a dressing, which does not fit the skin wound completely, and needs to be attached to materials such as non-woven fabrics, which affects the antibacterial effect. In view of this, the present invention proposes this invention especially. Conten...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0019A61L26/0023A61L26/0066A61L26/008A61L2300/404C08L5/08C08L71/02
Inventor 孙旭阳刘静
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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