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Coptis rhizome detoxification nasal temperature-sensitive gel and preparation method thereof

A temperature-sensitive, Rhizoma Coptidis technology, applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, antiviral agents, etc. Achieve process stability, improve bioavailability, safety and stability at room temperature

Active Publication Date: 2021-11-26
ZHANG ZHOU HALTH VOCATIONAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies of the prior art, the present invention provides a rhizome detoxification nasal temperature-sensitive gel and its preparation method to solve the existing technical problems of instability in vitro, limited application range, and low curative effect.

Method used

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  • Coptis rhizome detoxification nasal temperature-sensitive gel and preparation method thereof
  • Coptis rhizome detoxification nasal temperature-sensitive gel and preparation method thereof
  • Coptis rhizome detoxification nasal temperature-sensitive gel and preparation method thereof

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preparation example Construction

[0039] Preparation of Coptidis Rhizome Detoxification Nasal Thermosensitive Gel

[0040] Coptidis Rhizoma, Phellodendron Phellodendri, and 70% ethanol were added to reflux extraction twice, and the filtrates were combined and concentrated to 100mL, which was Concentrate A;

[0041] Scutellaria baicalensis, gardenia, decoct three times with water, combine the three filtrates, and concentrate to 100mL, which is concentrated solution B;

[0042] Take an appropriate amount of concentrated liquid A and concentrated liquid B, add the prescription amount of excipients P 407, P 188 and PEG 6000 to make it evenly dispersed, store it in a refrigerator at 4-10°C until P 407 is completely dissolved to obtain a clear gel Gel solution, namely Coptidis detoxification thermosensitive gel.

[0043] Determination of Gelation Temperature of Coptidis Rhizome Detoxifying Thermosensitive Gel

[0044] The gelling temperature was determined by the stir bar method. Put 20g of temperature-sensitive ...

Embodiment 1

[0046] 1) 45g Coptidis rhizome, 30g Cortex Phellodendri, add 6 times 70% ethanol to reflux and extract twice, each time for 1.5h, combine the two filtrates, concentrate to 100mL, and obtain concentrated solution A;

[0047] 2) Scutellaria baicalensis 30g, gardenia 45g, add 8 times of water and decoct three times, each time for 0.5h, combine the filtrates three times, concentrate to 100mL, and become concentrated solution B;

[0048]3) Precisely measure 20mL each of the concentrates A and B, add P407, P188 2g, PEG6000 2g, add deionized water to 100g, make it evenly dispersed, store in a refrigerator at 4-10°C until the auxiliary materials are completely dissolved to obtain The clear gel solution is Coptidis Rhizome Detoxifying Nasal Thermosensitive Gel. The amount of P407 was 18g, 20g, 22g, or 24g respectively, and its influence on the gelling temperature was investigated.

[0049] The experimental results showed that when the dosage of P188 and PEG6000 remained constant, the ...

Embodiment 2

[0051] The process is the same as in Example 1, the difference is:

[0052] Precisely measure 20mL each of the concentrates A and B, add 20g of P407, P188, 2g of PEG6000, add deionized water to 100g, make it evenly dispersed, and store it in a refrigerator at 4-10°C until the auxiliary materials are completely dissolved to obtain clarification. Gel solution, namely Coptidis Rhizome Detoxification Nasal Thermosensitive Gel. The amount of P188 was 1g, 2g, 3g, or 4g respectively, and its influence on the gelation temperature was investigated.

[0053] The amount of P188 was positively correlated with the gelation temperature, and T increased with the increase of P188. At a P188 concentration of 2%, the gelation temperature is close to the nasal cavity temperature, see figure 2 .

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Abstract

The present invention relates to the technical field of traditional Chinese medicine, and relates to a rhizome detoxification nasal temperature-sensitive gel and a preparation method thereof. The rhizome rhizome detoxification nasal temperature-sensitive gel is extracted from the concentrate of Coptis rhizome and Cortex Phellodendri extracts, Scutellaria baicalensis and gardenia It is prepared by mixing the concentrated solution of liquid, poloxamer 407, poloxamer 188, polyethylene glycol 6000, and water. The rhizome rhizome detoxification nasal temperature-sensitive gel provided by the invention overcomes the shortcomings of unstable active ingredients and difficulty in reaching the lesion, and has a simple preparation process, easy-to-obtain raw materials, clear drug efficacy, low irritation, safety and stability, and is suitable for antibacterial and anti-inflammatory applications. Wide range.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a rhizome rhizome detoxification nasal temperature-sensitive gel and a preparation method thereof. Background technique [0002] According to the theory of traditional Chinese medicine, the three medicines of Coptis chinensis, Scutellaria baicalensis and Cortex Phellodendri, referred to as "Sanhuang" for short, are commonly used medicines for clearing away heat, detoxifying and drying dampness in Chinese medicine. Jaundice, dysentery or fever caused by flaming heat and toxin, constipation, sores of the mouth and tongue, etc. are often used in combination with each other to improve the power of clearing away heat and detoxifying. Scutellaria baicalensis is good at clearing the fire of the upper burner, Coptis chinensis is good at clearing the fire of the middle burner, and Huangbai is good at clearing the fire of the lower burnt. [0003] Gardenia, also know...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/10A61K36/756A61P29/00A61P31/04A61P31/12
CPCA61K9/0043A61K9/06A61K36/539A61K36/718A61K36/744A61K36/756A61K47/10A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P29/00A61P31/04A61P31/12A61K2300/00
Inventor 谢伟容
Owner ZHANG ZHOU HALTH VOCATIONAL COLLEGE
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