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Traditional Chinese medicine peptide for treating chicken synovial bursa mycoplasma infection and preparation method thereof

A technology of mycoplasma synovium and traditional Chinese medicine, which is applied in the direction of medical formula, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problem of injuring chicken viscera, reduce damage, increase production rate, and improve drug efficacy Effect

Inactive Publication Date: 2019-03-08
河北肽都生物科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem of drug resistance and food safety caused by existing antibiotics, and the problem that traditional Chinese medicine prescriptions hurt chicken viscera, the invention provides a traditional Chinese medicine peptide for treating mycoplasma synovial bursa infection

Method used

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  • Traditional Chinese medicine peptide for treating chicken synovial bursa mycoplasma infection and preparation method thereof
  • Traditional Chinese medicine peptide for treating chicken synovial bursa mycoplasma infection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] This example provides a traditional Chinese medicine peptide for treating Mycoplasma synovialis infection. The raw materials include the following components in proportions by weight: 600 g of Bupleurum radiata, 600 g of licorice, 400 g of Scutellaria baicalensis, 400 g of Schizonepeta and 300 g of raw garlic. Its preparation method specifically comprises the following steps:

[0027] Step a. Weigh the above raw materials, add bupleurum, licorice, scutellaria baicalensis and Nepeta into 12L of purified water, stir evenly, cook at 90°C for 6h, then add raw garlic, and continue to cook for 0.5h;

[0028] Step b, lower the temperature to 56°C, add 23g of amylase (obtained from the fermentation of Aspergillus niger) and 11.5g of Aspergillus oryzae protease, stir at 56°C for enzymolysis for 3 hours, after the enzymolysis is completed, raise the temperature to 90°C, and keep for 10 minutes to kill the enzyme;

[0029] Step c, use a decanter centrifuge to centrifuge at a speed...

Embodiment 2

[0032] This example provides a traditional Chinese medicine peptide for the treatment of mycoplasma synovialis infection. The raw materials include the following components in parts by weight: Bupleurum bupleurum 1kg, licorice 0.4kg, Scutellaria baicalensis 0.6kg, Schizonepeta 0.6kg and raw garlic 0.2kg kg. Its preparation method specifically comprises the following steps:

[0033] Step a. Weigh the above raw materials, add bupleurum, licorice, scutellaria baicalensis and Nepeta into 16.9L of purified water, stir evenly, cook at 92°C for 6.5h, then add raw garlic, and continue to cook for 0.7h;

[0034] Step b. Cool down to 57°C, add 37g of amylase (obtained from fermentation of Aspergillus niger) and 18.6g of Aspergillus oryzae protease at 57°C and stir for 3 hours for enzymolysis.

[0035] Step c, use a decanter centrifuge to centrifuge at a rotating speed of 3600r / min, filter to remove solids, and then use a three-phase centrifuge to centrifugally filter and purify at a ro...

Embodiment 3

[0038] This example provides a traditional Chinese medicine peptide for treating mycoplasma synovialis infection. The raw materials include the following components by weight: Bupleurum bupleurum 12kg, licorice 8kg, Scutellaria baicalensis 8kg, Schizonepeta 8kg and raw garlic 4kg. Its preparation method specifically comprises the following steps:

[0039] Step a. Weigh the above raw materials, add bupleurum, licorice, scutellaria baicalensis and Nepeta into 270L of purified water, stir evenly, cook at 92°C for 6.5h, then add raw garlic, and continue to cook for 0.6h;

[0040] Step b, lower the temperature to 57°C, add 500g of amylase (obtained from the fermentation of Aspergillus niger) and 250g of Aspergillus oryzae protease, stir at 57°C for 3.5 hours, after the enzymolysis is completed, raise the temperature to 92°C, and keep for 15 minutes to kill the enzyme;

[0041]Step c, use a decanter centrifuge to centrifuge at a rotating speed of 3600r / min, filter to remove solids, ...

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Abstract

The invention relates to the technical field of veterinary medicine, in particular to traditional Chinese medicine peptide for treating chicken synovial bursa mycoplasma infection and a preparation method thereof. The traditional Chinese medicine peptide is prepared from the following raw materials: radix bupleuri, liquorice roots, radix scutellariae, herba schizonepetae and raw garlics. Five kinds of raw material medicine are combined to be used for achieving the effect of resisting the chicken synovial bursa mycoplasma infection; the damage to the internal organs of the chicken is small. Thepreparation method is characterized in that radix bupleuri, liquorice roots, radix scutellariae and herba schizonepetae are added to be boiled; then, the raw garlics are added to be continuously boiled; the boiled raw materials are subjected to enzymolysis by using amylase and neutral protease; solid liquid separation is performed; the obtained liquid is purified, concentrated and dried; the traditional Chinese medicine peptide is obtained. The product prepared by an enzymolysis technology has high active ingredients and small molecular weight; the dosage for treating the chicken synovial bursa mycoplasma infection is low.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a traditional Chinese medicine peptide for treating mycoplasma synovialum infection and a preparation method thereof. Background technique [0002] Chicken synovial mycoplasma infection is a chronic infectious disease caused by mycoplasma chicken synovial bursa that occurs in young chickens and turkeys, also known as chicken infectious synovitis. The disease develops slowly and has a long course. The sick chickens have poor spirits, rough feathers, emaciation, lying down, swelling of joints and parenchymal organs, inflammation of synovial bursa and tendons, and often manifest as lameness, which seriously affects the production capacity of chickens. . Mycoplasma synovialis is mainly transmitted through direct contact with the respiratory tract and through eggs, and can also be infected through blood-sucking insects. Caged chickens are not easy to be found after infec...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K36/8962A61P31/04
CPCA61K36/233A61K36/484A61K36/538A61K36/539A61K36/8962A61K38/011A61K2236/19A61K2236/331A61P31/04A61K2300/00
Inventor 张晓东杨广杨子丰
Owner 河北肽都生物科技集团有限公司
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