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Anti-oral ulcer drug and application thereof

A technology of oral ulcer and medicine, which is applied in the field of medicine, can solve the problems such as lack of detailed research reports, and achieve the effect of improving the anti-oral ulcer effect and promoting the effect

Inactive Publication Date: 2019-03-08
赵志波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether its therapeutic effect on oral ulcers is related to antioxidant activity, there is no detailed research report

Method used

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  • Anti-oral ulcer drug and application thereof
  • Anti-oral ulcer drug and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Gel for Oral Ulcers

[0027] Coniferyl Ferulate 4.5g

[0028] Carbomer 941 10g

[0029] Propylene glycol 100g

[0030] Glycerin 100g

[0031] Add purified water to 1000g

[0032] Preparation: Take 10g of Carbomer 941 and add 250g of purified water to fully swell overnight to make a matrix;

[0033] Take coniferyl ferulate 4.5g, add glycerin 100g, propylene glycol 100g, mix and slowly add to the matrix, stir at 600 rpm for 10 minutes to make the drug-loaded matrix;

[0034] Add purified water to the drug-loaded matrix to a total weight of 1000 g, stir at 400 rpm for 20 minutes to make a gel, and sterilize and dispense.

Embodiment 2

[0035] Example 2 Gel for Oral Ulcers

[0036] Coniferyl Ferulate 4.5g

[0037] α-Angelica lactone 0.6g

[0038] Carbomer 941 10g

[0039] Propylene glycol 100g

[0040] Glycerin 100g

[0041] Add purified water to 1000g

[0042] Preparation: Take 10g of Carbomer 941 and add 250g of purified water to fully swell overnight to make a matrix;

[0043]Mix 4.5 g of coniferyl ferulate and 0.6 g of α-angelica lactone, add 100 g of glycerin and 100 g of propylene glycol, mix and slowly add to the matrix, stir at 600 rpm for 10 minutes to make a drug-loaded matrix;

[0044] Add purified water to the drug-loaded matrix to a total weight of 1000 g, stir at 400 rpm for 20 minutes to make a gel, and sterilize and dispense.

Embodiment 3

[0045] Embodiment 3 The gel for oral ulcer

[0046] Coniferyl Ferulate 5.1g

[0047] α-Angelica lactone 0.6g

[0048] Carbomer 941 10g

[0049] Propylene glycol 100g

[0050] Glycerin 100g

[0051] Add purified water to 1000g

[0052] Preparation: Take 10g of Carbomer 941 and add 250g of purified water to fully swell overnight to make a matrix;

[0053] Mix 5.1 g of coniferyl ferulate and 0.6 g of α-angelica lactone, add 100 g of glycerin and 100 g of propylene glycol, mix and slowly add to the matrix, stir at 600 rpm for 10 minutes to make a drug-loaded matrix;

[0054] Add purified water to the drug-loaded matrix to a total weight of 1000 g, stir at 400 rpm for 20 minutes to make a gel, and sterilize and dispense.

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Abstract

The invention relates to the field of drugs, and in particular to an anti-oral ulcer drug and application thereof. The anti-oral ulcer drug is prepared from coniferyl ferulate or coniferyl ferulate and Alpha-angelica lactone as active components. The anti-oral ulcer drug is a locally delivered drug, such as gel, paste and collutory. Coniferyl ferulate which is locally delivered has the effect of promoting the healing of oral ulcers; and when coniferyl ferulate is used along with Alpha-angelica lactone, the effect of promoting the healing of oral ulcers is better.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a medicine for resisting oral ulcer and its application. Background technique [0002] Oral ulcer is a common oral mucosal disease, usually manifested as restricted mucosal keratinization at the ulcer site, appearing as white ulcer lesions. Clinical common oral ulcer can be divided into two kinds. Among them, the diameter of small ulcers is less than 1 cm and can heal spontaneously within 4 to 14 days. This ulcer accounts for 80 to 90% of clinical oral ulcers. The other is a large ulcer with a diameter of 1 to 3 cm. It usually takes 10 days to 6 weeks to heal spontaneously. As a self-healing disease, the main hazard of oral ulcers is pain. Although the lesions are small, they often affect eating and daily work. [0003] The cause of mouth sores is still unknown. At present, it is believed that the pathogenesis of oral ulcers may be related to microbial infection, neuropsyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/32A61K47/10A61K31/365A61K31/216A61P1/02
CPCA61K9/006A61K9/06A61K31/216A61K31/365A61K47/10A61K47/32A61P1/02
Inventor 赵永波邱艳梅孙丽丽赵志波
Owner 赵志波
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