Integrated microneedle patch and method for controlled drug release

Abstract

The invention discloses an integrated microneedle patch and method for controlled drug release. Among them, the integrated microneedle patch with controllable drug release includes: frictional nanogenerators, which generate alternating current for output; AC conversion DC circuit components, in which the input end is connected to the frictional nanogenerators to convert the alternating current generated by the triboelectrical nanogenerators into a direct current; and a microneedle array patch, which is connected to an output end of an AC conversion DC circuit element; wherein, the friction nanogenerator, the AC conversion DC circuit element and the microneedle array patch are integrated. The controllable release of microneedle drugs can be realized by gently tapping the patch, which not only simplifies the preparation process of microneedles, is conducive to large-scale production, but also improves the controllable release effect of microneedle drugs, and the drug loading is low. Affected.

Description

technical field [0001] The disclosure belongs to the field of triboelectric nanogenerators and microneedle-loaded drug release, and relates to an integrated microneedle patch and method for controllable drug release. Background technique [0002] Microneedles are manufactured by micro-electro-mechanical technology (MEMS), with a size of micron and a needle-like complex structure. [0003] The use of microneedle arrays can overcome the skin stratum corneum barrier in specific areas of the skin, enter the specific depth of the active epidermis, and generate hundreds of thousands of tiny holes, which can effectively promote drug permeation and accumulation in specific parts, and then drugs can pass through blood vessels and lymph glands absorbed and then introduced into the human circulatory system. Microneedle transdermal drug delivery can be implemented autonomously by patients, without the need for high proficiency and without pain. [0004] At present, the design of contr...

AI Technical Summary

Problems solved by technology

[0004] At present, the design of controllable microneedle drug delivery system taking into account both puncture and flexibility often requires the design of complex microneedle structures, and the complex production process is not suitable for large-scale production. volume is greatly affected

At the same time, for the widespread use of microneedles, it is preferable to use microneedle patches with simplified preparation process and structure, so that the controlled release effect of microneedle drugs is greatly reduced.

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