Simulated oral device and method of use for studying release of snus components

Abstract

The invention discloses a simulated oral cavity device for studying the release law of snus components and its use method, which includes an automatic injection pump, a plurality of syringes, a syringe jacket, a test tube and a constant temperature water bath, and the plurality of syringes are arranged on the automatic injection pump. The artificial saliva is inhaled into the syringe and connected to the syringe jacket through the catheter, the mouth smoke is placed in the syringe jacket, the syringe jacket is placed in the test tube in the constant temperature water bath and there is a gap with the bottom of the test tube; the bottom of the syringe jacket Leave an opening. The device and its use method can simultaneously collect the eluate of different or the same types of snus samples through multiple channels. After connecting multiple syringes to the automatic syringe pump, and then connecting a catheter to each syringe, it can be realized. Multiple snus samples were supplied with artificial saliva accurately, uniformly and quantitatively at the same time, and the eluate of different time periods was collected at any time.

Description

technical field [0001] The invention relates to the technical field of in vitro simulation devices, in particular to a simulated oral cavity device for studying the release law of snus components. Background technique [0002] In China, as a new type of tobacco product, snus in pouches has received more and more attention. Its use form is special, and the ingredients contained in it are directly released into the oral cavity. Therefore, its functionality as a tobacco product and its use during use safety cannot be ignored. When carrying out relevant researches, in vitro simulated oral devices are often used, but there are many deficiencies in the current settings of simulated oral devices. For example, temperature control cannot be carried out, and the temperature environment of the human oral cavity cannot be simulated, which may cause the measurement results to deviate from the actual value. In addition, the use part of snus is between the upper lip and the lower gum, and...

AI Technical Summary

Problems solved by technology

For example, temperature control cannot be carried out, and the temperature environment of the human oral cavity cannot be simulated, which may cause the measurement results to deviate from the actual value. In addition, the use part of snus is between the upper lip and the lower gum, and the two squeeze the snus , there will be a certain pressure, but the existing device cannot provide pressure, and there is residual eluate, and it is impossible to accurately monitor the eluate in different time periods

Images