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Degradable metal stent and preparation method thereof

A technology of metal stents and metal zinc, which is applied in the field of medical devices, can solve problems such as the toxicity of stent implantation sites, and achieve the effects of improving biological safety, simple preparation methods, and good operability

Active Publication Date: 2019-02-26
MICROPORT SINICA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] One of the objectives of the present invention is to provide a degradable metal stent to solve the problem of toxicity at the implantation site of the degradable metal stent in the prior art due to the release of metal ions

Method used

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  • Degradable metal stent and preparation method thereof
  • Degradable metal stent and preparation method thereof
  • Degradable metal stent and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0091] A preparation method of a degradable metal stent provided by the invention comprises the following steps:

[0092] S1: Cut the metal stent into a structure with accommodating space. After the cutting is completed, a drug coating can also be sprayed on the outer wall and / or inner wall of the stent. The drug coating includes a drug and a drug carrier. Pamycin, the drug carrier can be polylactic acid.

[0093] S2: preparing a chelating agent coating solution containing a chelating agent and a carrier.

[0094] S3: Add the chelating agent coating solution dropwise into the accommodating space, and wait for the solvent to volatilize.

[0095] S4: Repeat step S3 until the accommodating space is filled.

[0096] In another embodiment of the present invention, a method for preparing a degradable metal stent including a protective layer is also provided, and S1-S3 of the preparation method are the same as above, except that S4: repeat step S3 several times ; S5: Configure a coa...

Embodiment 1

[0103] Please refer to Figure 7 , is a partially enlarged view of a degradable metal stent provided by the present invention. The preparation method is as follows:

[0104] S1: Cut the degradable metal stent into a structure with through holes in the stent rod.

[0105] S2: Calcium sodium edetate (CaNa 2 EDTA) as chelating agent, PLA as carrier, solvent adopts n-propyl acetate. Prepare a solution of PLA and n-propyl acetate with a concentration of 2% (w / v); calcium sodium edetate (CaNa 2 EDTA) is dissolved in water at first into the higher mother liquor of concentration, then mother liquor is added dropwise in the n-propyl acetate solution that is dissolved with PLA, is stirred to evenly dissolving, obtains chelating agent coating solution, wherein CaNa EDTA final concentration in solution is 1.5 mg / mL.

[0106] S3: Add the chelating agent coating solution dropwise into the stent hole, and repeat the dropwise addition after the solvent evaporates until the stent hole is ...

Embodiment 2

[0109] Please refer to Figure 8 , is a partially enlarged view of a degradable metal stent provided in Example 2 of the present invention. Its preparation method is basically the same as that of Example 1, except that S1: the degradable metal stent is cut into a structure with a through hole in the stent rod, and rapamycin is sprayed on both surfaces of the stent, namely, the outer wall and the inner wall. Coated, drug loaded as polylactic acid.

[0110] In the degradable metal stent prepared according to the above method, the degradable metal stent is a stent with a drug coating, and the drug concentration of rapamycin per unit area of ​​the stent is 10 μg / mm 2 , the concentration of edetate calcium sodium per unit area is 15μg / mm 2 .

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Abstract

The invention provides a degradable metal stent and a preparation method thereof. The degradable metal stent is provided with a plurality of accommodating spaces, wherein each of the accommodating spaces is internally coated with a chelating agent coating containing a chelating agent. The degradable metal stent provided by the invention has the chelating agent coating which can chelate metal ionsreleased by the stent during degradation, so the toxicity of the metal ions can be controlled without influence on the complete degradation of the stent, the metal ions of the body of the stent are not interfered, and the biosafety of the degradable metal stent is effectively improved.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a degradable metal bracket and a preparation method thereof. Background technique [0002] Coronary stent implantation is an effective means of treating heart diseases caused by vascular blockage. From the development of the first generation of bare metal stents to the present, coronary stents have undergone three changes. [0003] The first-generation stent is a bare metal stent, which has a good effect of supporting blood vessels and has good endothelialization, but because it cannot inhibit the proliferation of vascular smooth muscle, it leads to a high probability of vascular restenosis. [0004] The second-generation stent is a metal stent with drug-sustained-release coating. The drug-sustained-release coating is prepared on the surface of the first-generation bare metal stent, and the drug is used to inhibit smooth muscle hyperplasia, which greatly reduces the incidence of rest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/02A61L31/08
CPCA61L31/022A61L31/08A61L31/148A61L2420/02
Inventor 王玄陈陆李俊菲
Owner MICROPORT SINICA CO LTD
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