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A kind of tetrapeptide and its preparation method and application

A peptide resin and amino acid technology, applied in the field of peptides, can solve problems such as lack of specificity, achieve the effects of inhibiting development, improving medical conditions, and improving medical conditions

Active Publication Date: 2020-11-06
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment of AD has always lacked effective drugs that are highly specific, relieve and reverse the disease, and improve the prognosis of the disease.

Method used

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  • A kind of tetrapeptide and its preparation method and application
  • A kind of tetrapeptide and its preparation method and application
  • A kind of tetrapeptide and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0061] Example 2 Anti-Aβ1-42 Protein Aggregation Activity Experiment of Synthetic Polypeptide IGFH in Vitro

[0062] 1. Experimental method

[0063] Preparation of culture medium: Take 35 mL of high glucose medium (DMEM), 4 mL of fetal bovine serum (FBS), 1 mL of L-glutamine, 40 μL of Hygromycin B and 20 μL of Blasticidin S antibiotics to prepare 40 mL of complete medium.

[0064] Preparation of 0.05, 0.1, 0.5 and 1mM synthetic polypeptide (IGFH) solutions: Weigh 4.7255mg of polypeptide IGFH, dissolve with 10mL of medium, pass through a 0.22μm filter head, the concentration of the mother solution is 1mM, and then use the medium to dissolve The mother liquor was diluted to the concentration required for the experiment.

[0065] Preparation of 2 mg / mL tetracycline solution: Weigh 10 mg of tetracycline, prepare with 5 mL of PBS buffer, pass through a 0.22 μm filter head, and store at -20°C in the dark for future use.

[0066] Hek293-E22G-mcherry cells were used for culture and ...

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Abstract

The invention relates to the technical field of polypeptides, in particular to a tetrapeptide and a preparation method and use thereof. Tetrapeptide Ile-Gly-Phe-His has a remarkable Abeta1-42 proteinaggregation resistance effect, thereby improving the memory and delaying Alzheimer's disease. The tetrapeptide Ile-Gly-Phe-His can be widely used for preparing foods and medicines resisting Abeta1-42protein aggregation, and can also be used for preparing foods and medicines for preventing or treating Alzheimer's disease. Therefore, the synthetic peptide can effectively prevent or treat AD and other neurodegenerative diseases, the medical condition of the neurodegenerative disease can be improved to a certain extent, and the tetrapeptide has great social and economic benefits.

Description

technical field [0001] The invention relates to the technical field of polypeptides, in particular to a tetrapeptide and its preparation method and application. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a multifactorially induced degenerative disease of the central nervous system, which mostly occurs in the elderly. The clinical manifestations of AD mainly include memory loss, cognitive decline, language impairment, and psychomotor abnormalities. The onset of the disease is slow or insidious, and it is more common in the elderly over 70 years old (average 73 years old for men, 75 years old for women). A small number of patients become clear quickly after physical illness, fracture or mental stimulation. With the intensification of population aging and the lack of effective prediction and treatment methods, the number of AD patients worldwide is on the rise. Due to the long-term course of AD, patients, their entire families an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/103C07K1/06C07K1/04C12N15/11A61K38/07A61P25/28A23L33/18
CPCA23L33/18A23V2002/00A61K38/00A61P25/28C07K5/101A23V2250/55A23V2200/322
Inventor 梁明尹西拳马忠华任娇艳
Owner INFINITUS (CHINA) CO LTD
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