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Preparation method and application of a molecular electrochemical sensor for sulfa drugs

A technology of sulfonamide drugs and molecular electrochemistry, applied in the direction of material electrochemical variables, scientific instruments, instruments, etc., can solve the problems of reduced sensitivity, reduced stability and reproducibility of electrochemical sensors, and limitations on the application of molecularly imprinted membranes. Achieve excellent electron transfer ability, convenient operation, and reduce detection cost

Active Publication Date: 2021-03-16
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electrochemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • Preparation method and application of a molecular electrochemical sensor for sulfa drugs
  • Preparation method and application of a molecular electrochemical sensor for sulfa drugs
  • Preparation method and application of a molecular electrochemical sensor for sulfa drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0031] The preparation of embodiment 1 Ni-nanoarray

[0032] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0033] (2) Weigh 1 mmol nickel nitrate hexahydrate Ni(NO 3 ) 2 ·6H 2 O and 3 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0034] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 100 °C for 12 hours to prepare the nickel hydroxide nanosheet array precursor body electrode;

[0035] (4) Insert the nickel hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, react at 20 °C for 4 hours, take it out and use Imme...

Embodiment 2

[0037] The preparation of embodiment 2 Ni-nanoarray

[0038] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0039] (2) Weigh 2 mmol nickel nitrate hexahydrate Ni(NO 3 ) 2 ·6H 2 O and 6 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0040] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 110 °C for 11 hours to prepare the nickel hydroxide nanosheet array precursor body electrode;

[0041] (4) Insert the nickel hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, react at 30 °C for 5 hours, take it out and use Dip ...

Embodiment 3

[0043] Example 3 Preparation of Ni-nanoarray

[0044] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0045] (2) Weigh 3 mmol nickel nitrate hexahydrate Ni(NO 3 ) 2 ·6H 2 O and 9 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0046] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 130 °C for 9 hours to prepare the nickel hydroxide nanosheet array precursor body electrode;

[0047] (4) Insert the nickel hydroxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, react at a temperature of 40 °C for 6 hours, take it out and us...

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Abstract

The invention discloses a preparation method of electrochemical sensor for sulfonamide molecule, and belongs to the technical field of new nano functional materials and biosensor. The method firstly prepares a nickel hydroxide nanosheet array on a disposable throwable electrode, and uses the large specific surface area and a high activity hydroxyl functional group and an amino functional group ofpolydopamine to sequentially prepare a polydopamine film containing an electron mediator and a molecularly imprinted polymer taking a sulfonamide molecule as a template molecule directly on the nickelhydroxide nanosheet array by adopting an in-situ growth method, after eluting the template molecule, the position of the original template molecule becomes a hole, that is, the molecularly imprintedpolymer eluting the template molecule, thus, an electrochemical sensor for the sulfonamide molecule is prepared.

Description

technical field [0001] The invention relates to a preparation method and application of an electrochemical sensor. It belongs to the technical field of new nano functional materials and chemical biosensors. Background technique [0002] Sulfonamide drugs are a general term for a synthetic antibacterial drug, a class of derivatives based on p-aminobenzenesulfonamide (referred to as sulfanilamide) as the basic structure, because they all contain p-aminobenzenesulfonamide structure, so they are collectively called sulfonamides Drugs are the most commonly used drugs. Due to the hydrogen on the sulfonamide group, it can be substituted by different heterocycles to form different kinds of sulfa drugs. Compared with the parent sulfonamide, they have the advantages of high potency, low toxicity, broad antibacterial spectrum, and easy absorption after oral administration. For example, sulfapyridine is the most commonly used, most effective, and most representative sulfa drug. It ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278
Inventor 刘召壹张勇魏琴
Owner UNIV OF JINAN
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