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A kind of sodium alginate/pineapple pomace nano-cellulose blended drug film and its preparation method and application

A technology of nano-cellulose and pineapple skin dregs, which is applied in the fields of pharmaceutical formulations, drug delivery, and medical preparations of non-active ingredients, etc., to achieve the effects of mild reaction conditions, simple process operation, and low equipment requirements

Active Publication Date: 2021-12-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, NCC is mostly used in composite materials, which can significantly improve the thermal stability, mechanical strength, hardness, rigidity and flexibility of materials, but there are relatively few studies on drug sustained release.

Method used

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  • A kind of sodium alginate/pineapple pomace nano-cellulose blended drug film and its preparation method and application
  • A kind of sodium alginate/pineapple pomace nano-cellulose blended drug film and its preparation method and application
  • A kind of sodium alginate/pineapple pomace nano-cellulose blended drug film and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Wash the pineapple peels until the water is transparent and crush the pineapple peels, use a filter cloth to separate the pineapple peels from the juice, then wash the pineapple peels until they are transparent, then dry them at 60°C for later use. Mix 50 g of cleaned pineapple skin dregs with 1 L of water, bathe in 75°C for 2 hours, filter the skin dregs with a filter cloth, clean them, add 7.5wt% sodium chlorite solution with pH 3.8, and bleach in a water bath at 75°C for 2 hours , then wash the skin dregs with clear water until white, then wash with 95wt% ethanol and dry. Finally, the dried sample was added to 10wt% NaOH solution for alkalization for 10 h, washed and dried, and crushed to obtain pineapple pomace cellulose (PPC).

[0037] (2) Mix pineapple pomace cellulose with 64% (w / w) sulfuric acid solution according to the ratio of solid to liquid 1:15 (g / mL), stir in a water bath at 45°C for 1.5h, and then use 10 times the volume of distilled water Added to ...

Embodiment 2

[0040] (1) Wash the pineapple peels until the water is transparent and crush the pineapple peels, use a filter cloth to separate the pineapple peels from the juice, then wash the pineapple peels until they are transparent, then dry them at 60°C for later use. Mix 50 g of the cleaned pineapple skin dregs with 750 mL of water, bathe in 70° C. for 3 h, filter the skin dregs with a filter cloth, and clean them up. Add 8 wt % sodium chlorite solution with pH 3.9 and bleach it in a water bath at 80° C. for 4 h. Afterwards, wash the skin dregs with clear water until white, and then dry them with 95% ethanol after washing. Finally, the dried sample was added to 12wt% NaOH solution for alkalization for 10 h, washed and dried, and crushed to obtain pineapple pomace cellulose (PPC).

[0041](2) Mix pineapple pomace cellulose with 64% (w / w) sulfuric acid solution according to the ratio of solid to liquid: 1:17.5 (g / mL), stir in a water bath at 47.5°C for 1.75h, and then use 10 times the v...

Embodiment 3

[0045] (1) Wash the pineapple peels until the water is transparent and crush the pineapple peels, use a filter cloth to separate the pineapple peels from the juice, then wash the pineapple peels until they are transparent, then dry them at 60°C for later use. Mix 50 g of cleaned pineapple skin dregs with 1100 mL of water, bathe in water at 80°C for 2.5 hours, filter the skin dregs with a filter cloth, clean them, add 7.75wt% sodium chlorite solution with pH 4.0, and bleach in a water bath at 70°C After 3 hours, wash the dregs with clean water until white, then wash with 95wt% ethanol and dry. Finally, the dried sample was added to 11wt% NaOH solution for alkalization for 10 h, washed and dried, and crushed to obtain pineapple pomace cellulose (PPC).

[0046] (2) Mix pineapple pomace cellulose with 64% (w / w) sulfuric acid solution according to the ratio of solid to liquid 1:20 (g / mL), stir in a water bath at 50°C for 2 hours, and then add 10 times the volume of distilled water ...

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Abstract

The invention discloses a sodium alginate / pineapple pomace nano-cellulose blended medicinal film as well as a preparation method and application thereof. The method uses sodium alginate and pineapple pomace nano-cellulose as raw materials, and the pineapple pomace is cleaned, dried, pulverized, bleached, and treated with lye to obtain pineapple pomace cellulose, and then the pineapple pomace is extracted by acid hydrolysis Nanocellulose, and then sodium alginate, pineapple peel nanocellulose and medicine are mixed simultaneously and poured into a mold to dry naturally to obtain a blended medicine film. The raw materials used in the invention have abundant sources, are convenient and easy to obtain, and have good economical efficiency. According to the invention, the process of preparing the drug film by blending the pineapple pomace cellulose with sodium alginate after modification is simple, the raw material is cheap, and the obtained composite drug film has good application prospects in the fields of drug sustained release and wound healing.

Description

technical field [0001] The invention belongs to the technical field of natural polymer-based composite drug-loaded films, and in particular relates to a sodium alginate / pineapple peel nano-cellulose blended drug film and a preparation method and application thereof. Background technique [0002] Pineapple is a famous fruit in tropical and subtropical regions and one of the most important fruits in the world. Currently, pineapple is grown in about 90 countries and regions around the world. The main producing areas are concentrated in Thailand, the Philippines, Indonesia, Brazil and South Africa. my country is one of the top ten main producing countries of pineapple, mainly distributed in Guangdong, Hainan, Guangxi, Fujian, Yunnan and other provinces. Pineapple can be eaten fresh or processed. The processed products are mainly canned pineapple and pineapple juice, but the utilization of the peel is still not high, and the peel accounts for 30-42% of pineapple processing waste....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/38A61K47/36
CPCA61K47/36A61K47/38A61K9/7007
Inventor 黄惠华罗苏芹戴宏杰
Owner SOUTH CHINA UNIV OF TECH
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