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Correlation of estrogen receptor alpha gene and female ophthalmopathy occurrence time

A technology of estrogen receptor and occurrence time, applied in the medical field, can solve the problems affecting the occurrence and development of female GO patients

Inactive Publication Date: 2019-02-01
张磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the XbaⅠ and PvuⅡ polymorphisms of ER-α gene affect the occurrence and development of female GO patients has not been reported yet

Method used

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  • Correlation of estrogen receptor alpha gene and female ophthalmopathy occurrence time
  • Correlation of estrogen receptor alpha gene and female ophthalmopathy occurrence time
  • Correlation of estrogen receptor alpha gene and female ophthalmopathy occurrence time

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Embodiment Construction

[0011] The present invention will be described in detail below in combination with specific embodiments.

[0012] 1 Objects and methods

[0013] 1.1 Object

[0014] Control group: normal women, age-matched, from women with ocular trauma in the ophthalmology ward of the Affiliated Hospital of Binzhou Medical College, female patients in the ophthalmic refraction clinic and women in the physical examination center.

[0015] Case group: From May 2011 to May 2012, female GD patients hospitalized in the Department of Ophthalmology and Endocrinology of the Affiliated Hospital of Binzhou Medical College, Binzhou City People's Hospital, and Binzhou Central Hospital were divided into case group 1 (GD group) , case group 2 (GO-S group), case group 3 (GO-L group).

[0016] Case group 1 (GD group): Female GD patients who were diagnosed as GD based on clinical symptoms and signs combined with blood thyroid hormone measurement and had no eye signs for more than 18 months. Diagnosis of GD ...

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Abstract

The invention discloses the correlation of an estrogen receptor alpha (ERalpha) gene and female ophthalmopathy occurrence time. In the aspect of ERalpha gene XbaI site polymorphism, the AA genotype isrelated to the occurrence of GD (Graves disease), is a susceptible genotype of GD, and is closely related to the occurrence time of GO, and is a risk factor for early onset of GO. The polymorphism ofERalpha gene PvuII restriction enzyme cutting site has no connection with the occurrence and development of GO.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to the correlation between the Xbal site polymorphism of the estrogen receptor alpha gene and the occurrence time of female Graves ophthalmopathy. Background technique [0002] Graves ophthalmopathy (GO) is an organ-specific autoimmune disease characterized by endocrine and orbital pathological manifestations, and is the most common orbital disease. Due to the effect of sex hormones on the immune system and gender differences, women are more prone to immune diseases. GO often occurs in patients with hyperthyroidism caused by toxic diffuse goiter (Graves, Disease, GD). Female GD patients are 7-10 times more than male patients. About 40% to 75% of hyperthyroid patients will develop GO. GO patients are male and female The ratio is 3:16, and the time of occurrence varies. Studies have confirmed that two single nucleotide polymorphisms of the estrogen receptor-α (estrogenreceptor-α, ER-...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156
Inventor 张磊
Owner 张磊
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