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Application of amino fullerenes in preparing antibacterial materials and antibacterial material

A technology of aminofullerene and antibacterial material is applied to the application of aminofullerene in the preparation of antibacterial materials and the field of antibacterial materials, and can solve the problems of non-selective antibacterial and the like

Inactive Publication Date: 2019-01-18
BEIJING FUNAKANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that fullerenes can only be antibacterial under light conditions and they do not have selective antibacterial properties, the present invention provides an application of aminofullerenes in the preparation of antibacterial materials. The aminofullerenes used do not require the aid of light Power can achieve effective antibacterial effect, that is, the aminofullerene used has the effect of dark toxicity antibacterial, and the aminofullerene used can also selectively antibacterial, and has no toxic side effects on normal cells

Method used

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  • Application of amino fullerenes in preparing antibacterial materials and antibacterial material
  • Application of amino fullerenes in preparing antibacterial materials and antibacterial material
  • Application of amino fullerenes in preparing antibacterial materials and antibacterial material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: Fullerene ethylenediamine C 70 (EDA) 8 Preparation, infrared spectroscopy detection and dynamic light scattering (DLS) test

[0051] (1) Fullerene ethylenediamine C 70 (EDA) 8 The preparation process

[0052] Fullerene ethylenediamine C 70 (EDA) 8 structural formula

[0053] (a) Weigh 50 mg (ie 0.0595 mol) of solid fullerene C with an analytical balance 70 (purity is 99%, Xiamen Funa New Material Technology Co., Ltd.) was dissolved in 25ml of o-xylene solution, ultrasonically dispersed for 30min, and 50mL (ie 0.75mol) ethylenediamine (analytical grade, national medicine reagent) was measured with a graduated cylinder, Add it into a 100mL Erlenmeyer flask with a stopper with a magnetic stirrer, stir for 24h using a magnetic stirrer at room temperature (rotating speed 1000r / min), use a solvent filter with a volume of 1L and a filter membrane pore size of 200nm (Jinteng Company) The reactant was suction-filtered to obtain a brown-red solution, and the ...

Embodiment 2

[0063] Example 2: Fuller allyl diamine C 70 (PDA) 6 Preparation, infrared spectroscopy detection and dynamic light scattering test

[0064] (1) Fuller allyl diamine C 70 (PDA) 6 The preparation process

[0065] Fuller allyl diamine C 70 (PDA) 6 structural formula

[0066] (a) Weigh 50 mg (ie 0.0595 mol) of solid fullerene C with an analytical balance 70 (purity is 99%, Xiamen Funa New Material Technology Co., Ltd.) was dissolved in 25ml of o-xylene solution, ultrasonically dispersed for 30min, and 60mL of propylenediamine (i.e. 0.7mol) was measured with a graduated cylinder (analytical grade, Sinopharm Reagent), Add it into a 100mL Erlenmeyer flask with a stopper with a magnetic stirrer, stir for 24h using a magnetic stirrer at room temperature (rotating speed 1000r / min), use a solvent filter with a volume of 1L and a filter membrane pore size of 200nm (Jinteng Company) The reactant was suction-filtered to obtain a brown-red solution, and the components of the soluti...

Embodiment 3

[0075] Example 3: Fullerene butanediamine C 70 (DAB) 2 Preparation, infrared spectroscopy detection and dynamic light scattering test

[0076] (1) Fullerene butanediamine C 70 (DAB) 2 The preparation process

[0077] Fullerene Butanediamine C 70 (DAB) 2 structural formula

[0078] (a) Weigh 50 mg (ie 0.0595 mol) of solid fullerene C with an analytical balance 70 (purity is 99%, Xiamen Funa New Material Technology Co., Ltd.) was dissolved in 25ml of o-xylene solution, ultrasonically dispersed for 30min, and 70mL of butanediamine (ie 0.7mol) was measured with a graduated cylinder (analytical grade, Sinopharm reagent), Add it into a 100mL Erlenmeyer flask with a stopper with a magnetic stirrer, stir for 24h using a magnetic stirrer at room temperature (rotating speed 1000r / min), use a solvent filter with a volume of 1L and a filter membrane pore size of 200nm (Jinteng Company) The reactant was suction-filtered to obtain a brown-red solution, and the components of the so...

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Abstract

The invention discloses an application of amino fullerenes in preparing antibacterial materials and an antibacterial material. Amino fullerenes used in this application include fullerene derivatives chemically bonded with organic amine groups on the surface of the fullerene feedstock, which are prepared by nucleophilic addition reaction of fullerenes and organic amine compounds. The amino fullerene used in the invention has good water solubility, small particle size, good dispersibility, is not easy to agglomerate, has positive charge on the surface, is easy to adsorb on the surface of the bacterial body, is easy to phagocytosis of the bacterial body, and has good free radical scavenging effect; and the amino fullerene used in the invention has good water solubility, small particle size, good dispersibility, is not easy to agglomerate, and is positively charged on the surface; At that same time, the invention has good antibacterial effect at low concentration, can achieve effective bactericidal effect without the aid of photodynamic force, can kill or inhibit gram-positive bacteria, gram-negative bacteria or fungi, can selectively kill or inhibit bacteria, has no toxicity to cells,and can be use for preparing antibacterial materials.

Description

technical field [0001] The invention relates to the field of antibacterial technology, in particular to the application of aminofullerene in the preparation of antibacterial materials and the antibacterial materials. Background technique [0002] Antibacterial agents refer to chemical substances that can keep the growth or reproduction of certain microorganisms (bacteria, fungi, yeast, algae, viruses, etc.) below the necessary level within a certain period of time, and have antibacterial and bactericidal properties. At present, there are many types of antibacterial agents on the market, but most of them have relatively large toxic and side effects. Therefore, the development of strong antibacterial, safe and non-toxic antibacterial agents has become a research hotspot for scientific and technological workers in various countries. [0003] Fullerenes are the most stable antioxidants found so far, without any toxicity to cells. The research on the antibacterial properties of...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P31/04A61P31/10
CPCA61K33/44
Inventor 王春儒张俊芳李慧李杰马海军
Owner BEIJING FUNAKANG BIOTECH CO LTD
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