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Application of rose acid d in anti-aging of hematopoietic stem cells

A technology of hematopoietic stem cells and roseic acid, applied in the field of biomedicine, can solve the problems of reduced hematopoietic function, immune function decline, hematopoietic stem cell function and quantity reduction, etc.

Active Publication Date: 2020-09-22
山东水发生命科学研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the basic components of the hematopoietic system are maintained during the aging process of the body, the function and number of hematopoietic stem cells gradually decrease, which leads to the decline of the body's hematopoietic function and immune function
There is no report on the anti-senescence of these compounds in hematopoietic stem cells

Method used

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  • Application of rose acid d in anti-aging of hematopoietic stem cells
  • Application of rose acid d in anti-aging of hematopoietic stem cells
  • Application of rose acid d in anti-aging of hematopoietic stem cells

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Embodiment Construction

[0016] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0017] 1. Experimental materials

[0018] Healthy and clean C57BL / 6J mice, male and female, 6-8 weeks old, weighing 18-20 g, were provided by the Animal Center of China Pharmaceutical University. Epoxycarotene A, Epoxycarotene B, Rose Acid A, Rose Acid B and Rose Acid D are self-made, with a purity of ≥98%, and are stored dry. Anti-Sca-1 MicroBead Kit was purchased from Miltenyi Company. SA-β-Gal Staining Kit was purchased from Cell Signaling Company. Methylcellulose medium MethoCult GF M3434 was purchased from Stem Cell Company.

[0019] 2. Experimental method

[0020] 1. Preparation of hematopoietic stem cell aging model and group intervention

[0021] C57BL / 6J mice were randomly divided into control group, model group and administration group (including epoxycarotene al...

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Abstract

The invention discloses an application of roseolic acid D in anti-senescence of hematopoietic stem cells. Hematopoietic stem cells undergo complex processes such as self-renewal, differentiation, aging and death to maintain the production of lifelong hematopoietic cells. Although the basic components of hematopoietic system are maintained during aging, the function and quantity of hematopoietic stem cells decrease gradually, which leads to the decrease of hematopoietic function and the decline of immune function. The invention shows that, Epoxycarotenal A, Epoxycarotenal B, Rosin A or Rosin Dcan resist senescence of hematopoietic stem cells by inhibiting transcription of p16 gene. Epoxycarotenal A, Epoxycarotenal B, Rosin A or Rosin D can be made into p16 gene transcription inhibitor andanti-senescence drug of hematopoietic stem cells.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to anti-aging of hematopoietic stem cells, in particular to an application of roseic acid D in anti-aging of hematopoietic stem cells. Background technique [0002] Hematopoietic stem cells undergo complex processes such as self-renewal, differentiation, aging and death to maintain the body's lifelong blood cell production. Although the basic components of the hematopoietic system are maintained during the aging process of the body, the function and number of hematopoietic stem cells gradually decrease, which leads to the decline of the body's hematopoietic function and immune function. [0003] At present, aging is considered to be a gene-related disease, and the tumor suppressor gene p16 is a key gene regulating cell aging. Studies have confirmed that when cells are senescent, the transcription and protein expression levels of p16 gene increase, inhibit cell mitosis, and stimulate the pho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/336A61K31/357A61K31/35A61K31/352A61P39/06
CPCA61K31/336A61K31/35A61K31/352A61K31/357A61P39/06
Inventor 荣大千雷云霆郑嘉荣区伟平
Owner 山东水发生命科学研究有限公司
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