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A kind of pharmaceutical composition and its application

A composition and drug technology, applied in the field of medicine, can solve problems such as unacceptable for patients and subcutaneous bleeding, and achieve the effects of convenient taking, improvement of clinical symptoms, and good compliance

Active Publication Date: 2019-07-26
沈洪彦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, at present, heparin or low-molecular-weight heparin is often treated by injection. The biggest disadvantage of heparin injection preparations in clinical practice is repeated injections. However, subcutaneous injections often cause subcutaneous bleeding, which is difficult for patients who need long-term medication.

Method used

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  • A kind of pharmaceutical composition and its application
  • A kind of pharmaceutical composition and its application
  • A kind of pharmaceutical composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 tablet

[0033]

[0034] Preparation process: mix the prescribed amount of propylthiouracil, low molecular weight heparin sodium, hydroxypropyl methylcellulose sodium, and microcrystalline cellulose, granulate according to the conventional process, dry, granulate, add magnesium stearate Mix well and press into tablets.

Embodiment 2

[0035] Example 2 tablet

[0036]

[0037]

[0038] Preparation process: Weigh the prescribed amount of propylthiouracil and heparin sodium through a 120-mesh sieve, microcrystalline cellulose and low-substituted hydroxypropyl cellulose through a 80-mesh sieve, mix well, add 2% hydroxypropyl methyl Appropriate amount of cellulose solution is granulated, dried at 40°C, granulated through a 16-mesh sieve, mixed with prescribed amount of magnesium stearate, and tabletted.

Embodiment 3

[0039] Example 3 tablet

[0040]

[0041] The preparation process is the same as in Example 2.

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PUM

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Abstract

The invention belongs to the medical field, in particular to an oral pharmaceutical composition and an application thereof in preparing a medicine for preventing or treating thyroid diseases. The pharmaceutical composition provided by the invention comprises an active ingredient thiopyrimidine drugs and heparin and lower molecular weight heparin. As proved by animal experiments and clinical experiment, the thiopyrimidines, the active ingredient of the medicine, the heparin and the low-molecular-weight heparin have good synergistic effect, have remarkable curative effect on hyperthyroidism, canobviously improve the clinical symptoms of the patient, and the recurrence rate is low; at the same time, the pharmaceutical composition of the invention is prepare into a solid oral preparation, which is convenient for patients to use and has good patient tolerance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral pharmaceutical composition and its application in the preparation of thyroid disease medicine. Background technique [0002] Hyperthyroidism, referred to as hyperthyroidism, is a syndrome involving multiple systems such as digestion, nerves, and circulation caused by excessive thyroid hormones that lead to hypermetabolism and abnormal excitement of the sympathetic nerves. It is a common disease in the Department of Endocrinology, and it is an immune disease. It is mainly caused by the excessive secretion of thyroid hormone in the patient. If you do not see a doctor in time at the early stage of the disease, it may even cause symptoms such as thyroid storm, thyroid eye disease, hyperthyroidism and heart disease. There are many patients with hyperthyroidism in my country, and its incidence rate is about 2%, especially in young and middle-aged women. [0003] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/727A61K31/505A61P5/16A61K9/20
CPCA61K9/2054A61K31/505A61K31/727A61P5/16A61K2300/00
Inventor 沈洪彦
Owner 沈洪彦
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