Composition comprising prostaglandin derivatives and ophthalmic liquid formulation comprising the composition
A technology of prostaglandins and derivatives, applied in the field of medicine, can solve problems such as adverse reactions, hair loss, liver toxicity, etc., and achieve the effect of avoiding the use of co-solvents and improving safety characteristics
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Embodiment 1
[0059] Example 1 Preparation of Ophthalmic Liquid Preparation Containing Latanoprost and Valproic Acid (1:16)
[0060] prescription
[0061]
[0062] Preparation
[0063] Mix and dissolve the prescribed amount of latanoprost, valproic acid, sodium chloride, edetate disodium, glycerin and benzalkonium chloride in 800mL water for injection, add the remaining amount of water for injection, sterilize, and pack , that is.
Embodiment 2
[0064] Example 2 Preparation of Ophthalmic Liquid Preparation Containing Bimatoprost and Sodium Valproate (1:6)
[0065] prescription
[0066]
[0067]
[0068] Preparation
[0069] Take the prescribed amount of travoprost, sodium valproate, sodium chloride, polyvinyl alcohol, benzalkonium chloride and carmellose sodium, mix and dissolve in 800mL water for injection, then add the remaining water for injection, and sterilize , sub-package, that is.
Embodiment 3
[0070] Example 3 Preparation of an ophthalmic liquid preparation comprising travoprost and divalproex sodium (1:15)
[0071] prescription
[0072]
[0073] Preparation
[0074] Take the prescribed amount of travoprost, divalproex sodium, sodium bisulfite, sodium chloride, glycerin and ethyl paraben, mix and dissolve in 800mL water for injection, then add the remaining amount of water for injection, sterilize, Subpackage, that is.
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