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Application of kaempferol in preparation of medicine for rheumatoid arthritis

A rheumatoid and kaempferol technology, applied in the field of biomedicine, can solve the problems of unsatisfactory treatment effect and limited treatment options, and achieve excellent anti-rheumatoid arthritis effect

Inactive Publication Date: 2019-01-11
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, although many new achievements have been made in the treatment of rheumatoid arthritis, the treatment options are still limited and the treatment effect is not satisfactory. Therefore, finding new drugs for the treatment of rheumatoid arthritis has important academic value and clinical significance

Method used

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  • Application of kaempferol in preparation of medicine for rheumatoid arthritis
  • Application of kaempferol in preparation of medicine for rheumatoid arthritis
  • Application of kaempferol in preparation of medicine for rheumatoid arthritis

Examples

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Effect test

Embodiment Construction

[0016] The present invention will be described in detail below in conjunction with specific embodiments.

[0017] In this example, the anti-rheumatoid arthritis effect of oral and intraperitoneal administration of kaempferol was evaluated by establishing a collagen-induced arthritis (CIA) model and using the clinical second-line drug leflunomide as a positive drug.

[0018] Drug source:

[0019] Kaempferol: Chengdu Master Biotechnology Co., Ltd., batch number: MUST-17032911.

[0020] Leflunomide: China National Institutes for Food and Drug Control, batch number: 100571-200601.

[0021] Experimental method: DBA / 1J mice (40, male, purchased from Changzhou Cavens Experimental Animal Co., Ltd., weighing 20±2 g) were used for the experiment. Under the standard feeding environment (eating and drinking freely, alternation of day and night, each 12 hours), adaptive feeding was carried out for one week. Subsequently, they were randomly divided into 5 groups, namely the control group...

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Abstract

The invention discloses the application of kaempferol in preparation of medicine for rheumatoid arthritis, especially oral administration, has excellent anti-rheumatoid arthritis effect, The effects of kaempferol on arthritis induced by collagen were studied by gastric perfusion and intraperitoneal injection. The effects of kaempferol on arthritis induced by collagen were studied, It was found that kaempferol had protective effect on collagen-induced arthritis model mice, and the effect was better than that of intraperitoneal administration, which was equivalent to the effect of leflunomide, apositive drug. It provided a optimal drug for clinical treatment of rheumatoid arthritis and related autoimmune diseases.

Description

technical field [0001] The invention belongs to biomedicine technology, and in particular relates to the application of kaempferol in the preparation of medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a kind of comprehensive, systemic, chronic autoimmune disease characterized by joint tissue lesions, whose pathogenesis is not yet clear, which can cause joint distortion and eventually lead to disability. It is recognized by the World Health Organization It is listed as one of the five intractable diseases in the world and is called "cancer that never dies". In recent years, although many new achievements have been made in the treatment of rheumatoid arthritis, the treatment options are still limited and the treatment effect is not satisfactory. Therefore, finding new drugs for the treatment of rheumatoid arthritis has important academic value and clinical significance . [0003] Kaempferol, molecular formula C 15 h 10 o 6...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P19/02A61P29/00
CPCA61K31/352A61P19/02A61P29/00
Inventor 王广基阿基业阿立翔
Owner CHINA PHARM UNIV
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