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EPA and DHA blending agent for preventing and treating anxiety and ahedonia

A technology of anhedonia and mixtures, applied in drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of differences, anti-inflammation, neuroprotective effects and mechanisms, etc.

Inactive Publication Date: 2018-12-21
GUANGDONG OCEAN UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although DHA is a downstream product of EPA, the actual anti-inflammatory and neuroprotective effects and mechanisms of the two are not the same
Today’s market is full of various EPA and DHA health care products, all of which claim to have preventive or adjuvant treatment effects, but the actual purity and mixing ratio vary greatly, and there is a lack of credible scientific evidence to support that it can effectively improve individual anxiety. , anhedonia, and actual improvement in anti-inflammatory and neuroprotective effects

Method used

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  • EPA and DHA blending agent for preventing and treating anxiety and ahedonia
  • EPA and DHA blending agent for preventing and treating anxiety and ahedonia
  • EPA and DHA blending agent for preventing and treating anxiety and ahedonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The ratio screening of embodiment 1 EPA and DHA

[0024] 1. Improvement effect on anxiety and anhedonia caused by central nervous system inflammation

[0025] 1. Experimental operation

[0026] C57 / BL6J mice were fed with 1% coconut oil, EPA or DHA in single or different ratios of EPA and DHA in the diet for 8 weeks. Then a ventricle implantation operation was performed. After a recovery period of one week, a single dose of LPS (5 µg) was administered centrally for 24 hours to stimulate the inflammatory response, and body weight and behavior were measured.

[0027] Among them, the ratio of EPA and DHA is EPA:DHA= 1:1, 1:2, 1:4, 2:1, 4:1 (weight ratio), respectively recorded as ED1-1, ED1-2, ED1-4 , ED2-1, ED4-1.

[0028] (1) Unilateral ventriculectomy

[0029] When the mice were about 12 weeks old, they were diluted 5 times with zoletil (50mg / ml) (ie 1mL zoletil + 0.1mL rompun + 3.9mL sterile saline) for deep anesthesia at 0.05-0.06mL per 10gm body weight, and the h...

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Abstract

The invention discloses application of an EPA and DHA blending agent in preparing a preparation for preventing and / or treating anxiety and ahedonia caused or deteriorated by nerve inflammation, wherein the mass ratio of EPA to DHA is 1 to (1.5-4). The EPA and DHA blending agent with the mass ratio expounded in the invention can effectively improve individual psychiatric symptoms such as the anxiety and ahedonia caused and deteriorated by the nerve inflammation and influences of actual physiological changes such as pressure level enhancement and weight loss, provides an adjuvant therapy reference which is applied in clinic in practice for neurodegeneration diseases such as dementia caused or deteriorated by melancholia or multiple kinds of nerve inflammation, and has an application prospectin preventing and treating relevant diseases.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of neuroinflammation, more specifically, relates to a mixture of EPA and DHA for preventing and treating anxiety and anhedonia. Background technique [0002] EPA and DHA can reach the central nervous system from the periphery through the blood-brain barrier, directly regulate nerve conduction, immune response, and hormone release, and affect various information transmissions by changing the characteristics of cell membranes, resulting in anti-inflammatory, neuroprotective, and neurogenesis effects. Fish oil and marine products are rich in EPA and DHA, which have also been clinically proven to have adjuvant therapeutic effects on emotional disorders such as depression and neurodegenerative diseases such as dementia and multiple sclerosis. [0003] Although DHA is a downstream product of EPA, the actual anti-inflammatory and neuroprotective effects and mechanisms of the two are diff...

Claims

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Application Information

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IPC IPC(8): A61K31/17A61K31/566A61P25/22A61P25/24
CPCA61K31/17A61K31/566A61P25/22A61P25/24A61K2300/00
Inventor 宋采梅玉莹张永平张才
Owner GUANGDONG OCEAN UNIVERSITY
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