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Preparation method of nanomaterial for preventing decayed teeth and treating superficial caries

A nano-material and dental caries prevention technology, applied in the field of nano-biotechnology and oral care, can solve the problems that antibiotics do not have broad-spectrum antibacterial ability, poor bacterial inhibition effect, and endanger public drug safety, so as to protect the surface structure of teeth, Inhibition of adhesion and proliferation, excellent broad-spectrum antibacterial ability

Active Publication Date: 2018-12-18
合肥诺创新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For a long time, antibiotics have been mainly used as antibacterial methods, but there are the following problems: 1) The abuse of antibacterial drugs has accelerated the evolution of bacteria to produce drug resistance, which has become a prominent problem that endangers the safety of public medication; 2) Most antibiotics do not have a broad spectrum Antibacterial ability, the effect on some bacteria is not good; 3) Antibiotics cannot be combined on the surface of the tooth, resulting in a short therapeutic effect, and after the saliva flows into the stomach and intestines, it is easily absorbed into the body circulation and enriched in other organs to produce toxic side effects

Method used

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  • Preparation method of nanomaterial for preventing decayed teeth and treating superficial caries
  • Preparation method of nanomaterial for preventing decayed teeth and treating superficial caries
  • Preparation method of nanomaterial for preventing decayed teeth and treating superficial caries

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A method for preparing nanomaterials for caries prevention and shallow caries treatment, comprising the following steps:

[0044] A. Evenly disperse polydopamine particles with a particle size of 50nm in the aqueous solution system, add the aqueous solution containing silver ions under magnetic stirring conditions, the mass ratio of polydopamine to silver ions is 1:0.1, and the reaction time is 0.5h. solution and rinsed with deionized water.

[0045] B, then the aqueous solution of alendronate (ALN) is slowly added in the high-speed stirring glutaraldehyde solution, the mol ratio of alendronate (ALN) and glutaraldehyde is 1:0.8, after reacting 5min, will The aqueous solution of the substance obtained in step A is slowly added to the solution system stirred at high speed, the mass ratio of the substance obtained in step A to alendronate (ALN) is 1:0.005, react for 1h, discard the supernatant by high-speed centrifugation and use deionized Water cleaning, vested.

[0046] ...

Embodiment 2

[0050] A method for preparing nanomaterials for caries prevention and shallow caries treatment, comprising the following steps:

[0051] A. Evenly disperse polydopamine particles with a particle size of 400nm in the aqueous solution system, add the aqueous solution containing silver ions under the condition of magnetic stirring, the mass ratio of polydopamine and silver ions is 1:10, the reaction time is 36h, and the supernatant is discarded by high-speed centrifugation solution and rinsed with deionized water.

[0052] B, then the aqueous solution of alendronate (ALN) is slowly added in the high-speed stirring glutaraldehyde solution, the mol ratio of alendronate (ALN) and glutaraldehyde is 1:1.2, after reacting 10h, will The aqueous solution of the substance obtained in step A was slowly added to the solution system stirred at high speed, the mass ratio of the substance obtained in step A to alendronate (ALN) was 1:1, reacted for 24h, and the supernatant was discarded by hig...

Embodiment 3

[0054] A method for preparing nanomaterials for caries prevention and shallow caries treatment, comprising the following steps:

[0055] A. Evenly disperse polydopamine particles with a particle size of 200nm in the aqueous solution system, add the aqueous solution containing silver ions under magnetic stirring conditions, the mass ratio of polydopamine to silver ions is 1:5, and the reaction time is 12h. The supernatant is discarded by high-speed centrifugation solution and rinsed with deionized water.

[0056] B, then the aqueous solution of alendronate (ALN) is slowly added in the high-speed stirring glutaraldehyde solution, the mol ratio of alendronate (ALN) and glutaraldehyde is 1:1, after reacting 5h, will The aqueous solution of the substance obtained in step A is slowly added to the solution system stirred at high speed, the mass ratio of the substance obtained in step A to alendronate (ALN) is 1:0.5, react for 12h, discard the supernatant by high-speed centrifugation ...

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Abstract

The invention discloses a preparation method of a nanomaterial for preventing decayed teeth and treating superficial caries, and relates to the fields of nano-biotechnologies and oral care technologies. The preparation method comprises the following steps: uniformly dispersing polydopamine particles in an aqueous solution system, adding an aqueous solution containing silver ions under a magnetic stirring condition, carrying out a reaction for a period of time, performing high-speed centrifuging, discarding the obtained supernatant, and washing the obtained reaction product with deionized water; and slowly adding an aqueous solution of molecules having the ability to recognize dental enamel to a high-speed stirred catalyst system solution, carrying out a reaction for a period of time, slowly adding the prepared antibacterial component-immobilized core aqueous solution to the obtained high-speed stirred solution system, carrying out a reaction for a period of time, performing high-speedcentrifugation, discarding the obtained supernatant, washing the obtained reaction product with deionized water to obtain the nanomaterial. The nanomaterial prepared by the preparation method is formed by the inner nanoparticle core having an induced mineralization effect, and an external containing the above broad-spectrum antibacterial component and the dental enamel recognition molecules.

Description

technical field [0001] The invention belongs to the technical fields of nano-biotechnology and oral care, and in particular relates to a preparation method of a nano-material used for caries prevention and shallow caries treatment. Background technique [0002] Caries is a common and frequently-occurring disease in humans, and its incidence rate remains high. The results of the third national oral health epidemiological survey show that the caries rate of deciduous teeth of 5-year-old children is as high as 66%, and the prevalence rate of permanent teeth of 12-year-old children is 28.9%, and the prevalence rate of caries among people over 35 years old is even higher 88%, and the prevalence gradually increased with age. This disease not only directly affects the healthy growth of children and adolescents, but also affects the quality of life of adults, so it is extremely urgent to find more effective and simple methods of caries prevention and treatment. [0003] Dental car...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/84A61K8/55A61K8/86A61Q11/00A61Q17/00A61K33/38A61K9/51A61K47/34A61K47/24A61P31/04A61P31/02A61P1/02
CPCA61K8/19A61K8/55A61K8/84A61K8/86A61K9/5123A61K9/5146A61K33/38A61K2800/413A61K2800/56A61Q11/00A61Q17/005A61P1/02A61P31/02A61P31/04
Inventor 陈佳龙王爽郭楚楚
Owner 合肥诺创新材料科技有限公司
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