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Sulfasalazine tablet preparation method

A sulfasalazine tablet and sulfasalazine technology are applied in the fields of sulfasalazine tableting mold, sulfasalazine tableting, and sulfasalazine tableting device, and can solve cost reduction and price increase , disadvantages and other problems, to achieve the effect of reducing cost, stable weight and simple structure

Active Publication Date: 2018-12-18
SUZHOU HUANGHE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Tablet pressing (tablet pressing is the process of pressing and processing materials and suitable auxiliary materials into tablet preparations with a tablet machine), each process needs to be equipped with special equipment, which leads to an increase in the price of traditional sulfasalazine production equipment. Helps reduce costs

Method used

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  • Sulfasalazine tablet preparation method
  • Sulfasalazine tablet preparation method
  • Sulfasalazine tablet preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1, this embodiment is a mold for making sulfasalazine tablets.

[0075] see Figure 1-Figure 9 The tablet-making mold of sulfasalazine in this embodiment includes a tablet-making mold 1 , and the tablet-making mold 1 includes an upper mold 11 , a lower mold 12 and a stopper 13 .

[0076] The upper mold 11 is provided with a penetrating tablet-making chamber 111 , and the lower mold 12 is provided with a tablet-making jack post 121 , and the tablet-making jack post 121 is inserted into the tablet-making chamber 111 snugly. Usually, the cross-section of the film-making chamber 111 and the cross-sectional shape of the film-making push column 121 are the same and are circular. The section of the film chamber 111 and the section of the film-making top column 121 are square, triangular or the like. Usually, the upper mold 11 and the lower mold 12 are made of medical stainless steel or medical ABS.

[0077] The limiting member 13 includes a limiting bar 131 , the...

Embodiment 2

[0086] Embodiment 2, this embodiment is a tablet-making device for sulfasalazine.

[0087] see Figure 10-Figure 15 , The sulfasalazine tablet-making device of this embodiment includes a tablet-making device 2 , and the tablet-making device 2 includes a transport unit 21 ; the transport unit 21 includes a transport device 211 . The conveying device 211 is usually a power belt, and may also be a linear conveying device such as a power chain or a power chain plate. Usually, the conveying part 21 further includes a frame 212 fixedly connected with the conveying device 211 for supporting the conveying device 211 .

[0088] The tablet making device 2 also includes a coating machine 22 fixedly arranged above the conveying device 211 . Usually, the coater 22 is a conventional roller coater [in the accompanying drawings, the details of the coater 22 are drawn], such as the DCM-36 coater of Nanjing Xiante Automation Equipment Co., Ltd., of course It can be a coating machine of other...

Embodiment 3

[0102] Embodiment 3, this embodiment is a method for preparing tablets of sulfasalazine.

[0103] Sulfasalazine tablet preparation method, comprises the following steps:

[0104] S1, mixing and stirring sulfasalazine powder and water to make sulfasalazine ointment 3. In the sulfasalazine powder, one or more of conventional disintegrants (such as starch, etc.), lubricants, and glidants (such as talc powder, micronized silica gel, hydrogenated vegetable oil, etc.) are usually added. Mixing, stirring is usually done in a conventional blender. Sulfasalazine ointment 3 usually determines the appropriate penetration through experiments to facilitate application.

[0105] S2, coating the sulfasalazine ointment 3 on the tablet-making mold 1 to obtain the tablet-making mold 1 coated with the sulfasalazine ointment 3 . The coating of the sulfasalazine ointment 3 is usually completed on the above-mentioned tablet making device 2 .

[0106] In S2, a step S21 of extruding the tablet-ma...

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Abstract

The invention relates to a sulfasalazine tablet preparation method. According to the method, a tablet preparation mold is adopted. The tablet preparation mold comprises an upper mold, a lower mold anda locating part. The upper mold is provided with a tablet preparation cavity which penetrates through the upper mold. The lower mold is provided with tablet preparation top columns. The tablet preparation top columns are respectively and fittingly inserted into the tablet preparation cavity. The locating part comprises a locating strip. The top end surface of the locating strip and the bottom endsurface of the locating strip abut against the upper mold and the lower mold respectively. The preparation method comprises the following steps: mixing up sulfasalazine powders with water, and stirring the mixture to prepare a sulfasalazine ointment; coating the sulfasalazine ointment on the tablet preparation mold to obtain the tablet preparation mold coated with the sulfasalazine ointment; drying the tablet preparation mold coated with the sulfasalazine ointment to obtain the tablet preparation mold loaded with a sulfasalazine tablet; driving the upper mold to get close to the lower mold soas to push out the sulfasalazine tablet by the tablet preparation top columns and obtain the sulfasalazine tablet. According to the invention, the sulfasalazine tablet preparation method is simple inprocess and the cost is reduced. The preparation method disclosed by the invention can be used for ensuring the weight stability of the sulfasalazine tablet.

Description

technical field [0001] The invention relates to the technical field of sulfasalazine production, in particular to a sulfasalazine tablet-making mold, a corresponding sulfasalazine tablet-making device, and a corresponding sulfasalazine tablet-making method. Background technique [0002] The traditional production of sulfasalazine is all through, [0003] Crushing (crushing is mainly the operation process of finely pulverizing solid materials by mechanical force), [0004] Sieving (sieving is the operation of separating mixed materials of different particle sizes according to particle size), [0005] Mixing (mixing is the operation of uniformly mixing two or more components) [0006] Granulation (granulation is the operation of processing materials in the state of powder, molten liquid, aqueous solution, etc. into granular objects with a certain shape and size), [0007] Drying (drying is the operation of using heat energy to vaporize the moisture in the material, and usin...

Claims

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Application Information

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IPC IPC(8): A61J3/00
CPCA61J3/00A61J2200/20A61J2200/42
Inventor 肖祖华江尔胜
Owner SUZHOU HUANGHE PHARMA CO LTD
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