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Application of FTY720 to preparation of drugs used for inhibiting neuronal apoptosis

A technology of nerve cell apoptosis, 1. FTY720, applied in the field of medicine

Inactive Publication Date: 2018-11-16
WENZHOU CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a use of FTY720 in the preparation of drugs for inhibiting nerve cell apoptosis, so as to solve the problems that are not reported in the prior art

Method used

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  • Application of FTY720 to preparation of drugs used for inhibiting neuronal apoptosis
  • Application of FTY720 to preparation of drugs used for inhibiting neuronal apoptosis
  • Application of FTY720 to preparation of drugs used for inhibiting neuronal apoptosis

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Embodiment Construction

[0021] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. The inventors came to the conclusion of the present invention through the following experiments. details as follows:

[0022] 1. Test materials and methods

[0023] 1. Material:

[0024] Healthy Wistar rats (provided by the Institute of Model Animals, Nanjing University), male, clean grade, weighing 250-300 g; FTY720 (lot number: SML0700, Sigma, USA) were prepared into 1 mL injection with normal saline according to the dosage before use; microplate reader (model: MK3, American Thermo Scientific Company); interleukin-1βELISA kit (lot number: M6000B, American R&D company), tumor necrosis factor-αELISA kit (lot number: MTA00B, American R&D company), interleukin-6 ELISA kit (lot number: MTA00B, American R&D company), interleukin-6 ELISA kit (lot number: : MLB00C, American R&D Company); TUNEL kit (lot number: MK1024, Wuhan Boster Biologica...

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Abstract

The invention discloses application of FTY720 to preparation of drugs used for inhibiting nerve cell apoptosis. FTY720 can inhibit inflammatory reactions, reduce cell apoptosis and alleviate secondarycerebral injury, thereby improving the prognosis of craniocerebral injury. Furthermore, results of injection of different doses of FTY720 into hippocampi of rats show that the proportion of apoptoticnerve cells, the activity of caspase-3 protein and the concentrations of interleukin-1beta, tumor necrosis factor-alpha and interleukin-6 in the hippocampi of a small-dose rat group, a middle-dose rat group and a large-dose rat group are significantly decreased compared with a model group, and are dose-dependent; thus, it is proved that a certain dose of FTY720 can effectively inhibit nerve cellapoptosis.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the use of FTY720 in the preparation of medicines for inhibiting nerve cell apoptosis. Background technique [0002] Traumatic brain injury is a common form of trauma, the prognosis is often not ideal. The combined effect of primary brain injury and secondary brain injury affects the prognosis of patients with traumatic brain injury. The use of drugs can reduce secondary brain injury, thereby improving patient outcomes. Inflammation and apoptosis are important mechanisms of secondary brain injury after traumatic brain injury. Generally speaking, craniocerebral injury can activate the glial cells of the central nervous system, thereby releasing a large amount of cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6, and then activating the apoptotic protein caspase 3. As an apoptosis executor, caspase 3 can directly degrade intracellular structural and ...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61P25/28
CPCA61K31/137A61P25/28
Inventor 蔡建勇林群巴华君吴艳陈献东陆川孙军陈茂华
Owner WENZHOU CENT HOSPITAL
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