Markers for the diagnosis of nasopharyngeal carcinoma

Abstract

The invention discloses a marker for the diagnosis of nasopharyngeal carcinoma, the group of markers includes TCRBV5.4, TCRBV6.3, TCRBV6.4, TCRBV6.6, TCRBV6.7, TCRBV7.9, TCRBV8.1, TCRBV10 .2, TCRBV10.3, TCRBV12.3, TCRBV12.4, TCRBV15, TCRBV20.1, TCRBV22, TCRBV25.1, and constructed a nasopharyngeal carcinoma diagnostic formula through the LASSO model, and obtained the prediction of nasopharyngeal carcinoma based on these TCR genes Method, after ROC detection, the AUC value of the diagnostic formula in the test group reached 0.96, when the sensitivity was 0.95, the specificity was 0.86; the AUC value in the verification group was 0.74, when the sensitivity was 0.79, the specificity was 0.75, The diagnostic performance is good.

Description

technical field [0001] The invention relates to a marker for nasopharyngeal carcinoma diagnosis. Background technique [0002] Nasopharyngeal carcinoma is currently a disease with a high cure rate, and the key lies in early diagnosis and timely treatment. Therefore, the screening and diagnosis of nasopharyngeal carcinoma is particularly important. However, due to the hidden anatomical location of the nasopharynx, the early symptoms of nasopharyngeal carcinoma are not obvious, which brings certain difficulties to the early diagnosis of nasopharyngeal carcinoma. [0003] At present, the main auxiliary examination methods for nasopharyngeal carcinoma include electronic nasopharyngoscopy, nasopharyngeal CT and serological examination of EB virus. The electronic nasopharyngoscope has strong illumination and clear images. It can dynamically observe the whole picture of the nasopharynx, and can find tiny hidden lesions in the nasopharynx. However, because the electronic nasophary...

AI Technical Summary

Problems solved by technology

The electronic nasopharyngoscope has strong illumination and clear images, and can dynamically observe the whole picture of the nasopharynx, and can find tiny hidden lesions in the nasopharynx. However, because the electronic nasopharyngoscope cannot find submucosal lesions, there are also some false negatives

CT image resolution is very high, it is more economical and practical, and the skill can distinguish bone and soft tissue. The equipment is relatively popular, and it is a commonly used method in the diagnosis of nasopharyngeal carcinoma. Early lesions with small volume in hidden parts are often difficult to find, especially in isodense lesions. At the same time, local verification, secretions and lymphoid tissue make it difficult to judge the symmetry of nasopharyngeal carcinoma on CT.

Studies have shown that Epstein-Barr virus is closely related to the occurrence and development of nasopharyngeal carcinoma. Epstein-Barr virus serological examination, as an auxiliary indicator for the diagnosis of nasopharyngeal carcinoma, has certain guiding significance in nasopharyngeal carcinoma, but there are certain false positives in this method, not only Increased clinical workload and brought unnecessary pressure to the subjects

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