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Method for efficiently synthesizing Neotame

A neotame and high-efficiency technology, applied in the field of food additives, can solve the problems of low product purity, complicated operation, high cost, etc., and achieve the effect of less reaction impurities, simple operation and short reaction time

Active Publication Date: 2018-10-19
NANTONG CHANGHAI FOOD ADDITIVE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome defects such as high cost, low product purity, low yield and complicated operation of the synthetic method of neotame in the prior art, and provide a kind of preparation neotame with simple process, convenient operation, cost saving, environmental protection and safety Methods

Method used

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  • Method for efficiently synthesizing Neotame
  • Method for efficiently synthesizing Neotame
  • Method for efficiently synthesizing Neotame

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Pump 100kg of ethanol into a 500-liter high-pressure reactor, add 12.5kg (42.5mol) of aspartame, and then add 4.2kg of 3,3-dimethylbutyraldehyde (41.9mol), stir and dissolve, and add 0.45Kg of Raney nickel Catalyst, close the valve, replace the system with hydrogen after nitrogen replacement three times, keep the hydrogen pressure in the system at 1.0Mpa after the replacement, start stirring, adjust the speed to 30 (equivalent to 180r / min), heat with hot water, and control the reaction temperature at 50°C. After 2 hours of heat preservation and hydrogenation, the hydrogen gas was discharged, the catalyst was removed by pressure filtration, ethanol was removed by vacuum distillation, the catalyst was recovered, the filtrate was cooled to -5°C to crystallize, and the centrifuge was centrifuged to obtain the neotame product, with a yield of 97% based on aspartame. Purity (HPLC) 99.83%.

Embodiment 2

[0028] Pump 500kg of tetrahydrofuran into a 1000-liter high-pressure reactor, put in 62.5kg (212.4mol) of aspartame, and then put in 23.4kg of 3,3-dimethylbutyraldehyde (233.6mol), stir and dissolve, and put in 2.25Kg of Raney Nickel catalyst, close the valve, replace the system with hydrogen after nitrogen replacement three times, keep the hydrogen pressure in the system at 1.2Mpa after the replacement, start stirring, adjust the speed to 30 (equivalent to 180r / min), heat with hot water, and control the reaction temperature at 60°C , after 2 hours of heat preservation hydrogenation, the hydrogen gas is discharged, the catalyst is removed by pressure filtration, and tetrahydrofuran is removed by vacuum distillation, the catalyst is recovered, the filtrate is cooled to 10°C to crystallize, and the centrifuge is centrifuged to obtain the neotame product, with a yield of 96% based on aspartame. Purity (HPLC) 99.63%.

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Abstract

The invention provides a method for efficiently synthesizing Neotame. Aspartame, 3,3-dimethylbutyraldehyde and organic solvent are synthesized into the Neotame under the hydrogenation of catalyst. Themethod has the advantages of low raw material cost, short reaction time, simpleness in operation and few reaction impurities, the yield of a finished product is 95% or more, the quality of the finished product conforms to the requirement of the united states pharmacopeia, and the finished product is favorable for industrial production and has a good production prospect.

Description

technical field [0001] The invention belongs to the field of food additives, in particular to a method for efficiently synthesizing neotame. Background technique [0002] Neotame is a new type of non-nutritive high-efficiency sweetener, its chemical name is N-[N-3,3-dimethylbutyl]-L-ɑ-aspartame]-L- Phenylalanine 1-methyl ester, its structural formula is as follows: [0003] [0004] Neotame is a derivative of aspartame (APM), which belongs to a new type of dipeptide strong sweetener. It is currently recognized as the strongest sweetener in the world. Its sweetness is 7000 to 12000 times that of sucrose. It is 50 times that of aspartame, and neotame has a pure sweetness similar to sucrose and good stability, and is widely used in processed foods such as bread, beverages, cakes, dairy products, ice cream, jelly pudding, jams, and fruits and vegetables middle. Neotame can also be used as a flavor enhancer, not only suitable for people including obesity, diabetes and cardi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/075C07K1/14
CPCC07K5/0613
Inventor 庄勇王立平赵海东顾京城
Owner NANTONG CHANGHAI FOOD ADDITIVE
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