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Application of four compounds in preparation of nematicidal medicines

A nematicide and compound technology, applied in the direction of nematicide, application, drug combination, etc., can solve the problems of high residue and high toxicity, achieve obvious curative effect, drive away nematode parasites, and have no drug dependence

Active Publication Date: 2018-10-02
INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing agricultural nematicides mainly include organophosphorus pesticides such as nematosphate, which have the disadvantages of high toxicity and high residue; medical anthelmintics include albendazole, which also has certain side effects

Method used

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  • Application of four compounds in preparation of nematicidal medicines
  • Application of four compounds in preparation of nematicidal medicines
  • Application of four compounds in preparation of nematicidal medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: prepare the agricultural water solvent of the compound of the present invention

[0037] Weigh raw materials according to weight (unit: g): 4,5′-dihydroxy-3,5-dimethoxybibenzyl, 3,3′,4′-trihydroxy-4,5-dimethoxybibenzyl Benzyl, methyl p-hydroxyphenylpropionate and trans-ethyl p-hydroxycinnamate 12g each, Tween-60 4g four parts, water 100mL four parts.

[0038] Add 100mL of Tween-60 and heat to 50-60 degrees Celsius, slowly add 4,5′-dihydroxy-3,5-dimethoxybibenzyl, 3,3′,4′-trihydroxy-4,5 - Dimethoxybibenzyl, methyl p-hydroxyphenylpropionate and trans-ethyl p-hydroxycinnamate, filtered to obtain four aqueous solutions.

[0039] Agriculture can be used to kill nematodes by diluting 100mL of the prepared aqueous solution to 4000mL with water for spraying or rhizosphere injection.

Embodiment 2

[0040] Embodiment 2: Preparation of capsules of the compound of the present invention

[0041] Weigh each raw material according to the following weight (unit: g): 4,5′-dihydroxy-3,5-dimethoxybibenzyl, 3,3′,4′-trihydroxy-4,5-dimethyl 50g each of oxybibenzyl, methyl p-hydroxyphenylpropionate and trans-ethyl p-hydroxycinnamate.

[0042]4,5'-dihydroxy-3,5-dimethoxybibenzyl, 3,3',4'-trihydroxy-4,5-dimethoxybibenzyl, methyl p-hydroxyphenylpropionate and Add 100 mL of ethanol to trans-ethyl p-hydroxycinnamate, filter, add 1.8 g of sodium starch glycolate, mix well, spray dry to make granules, and put them into No. 1 capsules to obtain capsules.

Embodiment 3

[0043] Example 3: Preparation of Tablets of Compounds of the Invention

[0044] Weigh each raw material according to the following weight (unit: g): 4,5′-dihydroxy-3,5-dimethoxybibenzyl, 3,3′,4′-trihydroxy-4,5-dimethyl 50g each of oxybibenzyl, methyl p-hydroxyphenylpropionate and trans-ethyl p-hydroxycinnamate.

[0045] 4,5'-dihydroxy-3,5-dimethoxybibenzyl, 3,3',4'-trihydroxy-4,5-dimethoxybibenzyl, methyl p-hydroxyphenylpropionate and Add 100 mL of ethanol to trans-ethyl p-hydroxycinnamate, filter, add 1.8 g of sodium starch glycolate, mix thoroughly, spray dry to make granules, and send to a tablet machine for tableting.

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Abstract

The invention relates to the technical field of pesticides and pharmaceuticals and particularly relates to the application of four compounds in preparation of nematicidal medicines. The four compoundsdisclosed by the invention are safe and reliable, are capable of effectively controlling nematodiasis agriculturally and expelling nematoid parasites medicinally, do not have any toxic and / or side effects or drug dependence to the human body, are better than existing pesticides and pharmaceuticals, and can be widely applied to the preparation of nematicidal medicines.

Description

technical field [0001] The invention relates to the technical fields of pesticides and medicines, in particular to the application of four compounds in the preparation of nematicides. Background technique [0002] Nematode refers to the general term belonging to the nematode animal phylum. There are many kinds of records, which can be seen everywhere in the world. Many of them are parasitic. Among them, there are as many as 25 kinds of parasitic nematodes recorded in my country, and the more popular ones are roundworms, pinworms and hookworms. . With the improvement of medical and sanitation conditions, the infection rate of soil-transmitted nematodes in my country has been reduced from 20.88% to 3.12% in 2005-2013, but it still poses a great threat to people's health. And agricultural and forestry nematodes are also very harmful, resulting in reduced agricultural production (such as root-knot nematode, which is estimated to cause global crop losses of 100 million US dollars...

Claims

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Application Information

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IPC IPC(8): A01N31/16A01N37/38A01P5/00A61K31/216A61K31/09A61P33/10
CPCA01N31/16A01N37/38A61K31/09A61K31/216A61P33/10A61K2300/00
Inventor 黄圣卓梅文莉王辉蔡彩虹谭彩银周丽曼王军戴好富
Owner INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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