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Carbetocin injection

A carbetocin and injection technology, which is applied in the field of medicine, can solve the problems of uterus increasing the suffocation in childbirth and the limited effect, and achieve the effects of shortening the farrowing interval, shortening the labor process, and improving the effect of uterine contraction.

Active Publication Date: 2018-09-25
NINGBO SANSHENG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Carbetocin injection alone has been widely used in the livestock industry, but the effect of using carbetocin alone is limited, and if it is not handled properly, it will lead to intense contraction of the uterus and increase the amount of asphyxia during childbirth

Method used

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  • Carbetocin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The carbetocin injection of this embodiment includes carbetocin, sodium alginate, vitamin D2, benzyl alcohol and sodium acetate, and the composition of every 2mL carbetocin injection is: carbetocin The content of sodium alginate is 70 μg, the content of sodium alginate is 6 mg, the content of vitamin D2 is 3 mg, the content of benzyl alcohol is 1.9 mg and the content of sodium acetate is 27 mg. Acetic acid is used as a pH regulator to adjust the pH to 4.0, and the balance is water for injection.

[0027] Weigh 90% of the prescribed amount of water for injection into the batching tank, add the prescribed amount of sodium alginate, vitamin D2, benzyl alcohol and sodium acetate, dissolve and mix well, adjust the pH value to 4.0 with acetic acid, and then add carbetocin , stirred at 80rpm for 40min at 50°C, dissolved and mixed evenly, cooled to 25°C, added water for injection to make up to volume, after constant volume, passed secondary filtration through 0.45μm and 0.22μm p...

Embodiment 2

[0029] The carbetocin injection of this embodiment includes carbetocin, pectin (65% esterification degree, molecular weight of 150,000), vitamin D2, benzyl alcohol and sodium acetate, and every 2mL of carbetocin The composition of the injection is: the content of carbetocin is 70 μg, the content of pectin (65% esterification, molecular weight is 150,000) is 6 mg, the content of vitamin D2 is 3 mg, the content of benzyl alcohol is 1.9 mg and sodium acetate The content is 27 mg, using acetic acid as the pH regulator, using acetic acid as the pH regulator to adjust the pH to 4.0, and the balance being water for injection.

[0030]Weigh 90% of the prescribed amount of water for injection into the batching tank, add the prescribed amount of pectin, vitamin D2, benzyl alcohol and sodium acetate, dissolve and mix, adjust the pH value to 4.0 with acetic acid, then add carbetocin, Stir at 80rpm for 40min at 50°C, dissolve and mix well, then cool to 25°C and add water for injection to m...

Embodiment 3

[0032] The carbetocin injection of this embodiment includes carbetocin, pectin (40% esterification degree, molecular weight of 150,000), vitamin D2, benzyl alcohol and sodium acetate, and every 2mL of carbetocin The composition of the injection is as follows: the content of carbetocin is 70 μg, the degree of pectin esterification is 40%, the molecular weight is 150,000), the content is 6 mg, the content of vitamin D2 is 3 mg, the content of benzyl alcohol is 1.9 mg and the content of sodium acetate 27mg, use acetic acid as the pH regulator, use acetic acid as the pH regulator, adjust the pH to 4.0, and the balance is water for injection.

[0033] Weigh 90% of the prescribed amount of water for injection into the batching tank, add the prescribed amount of pectin, vitamin D2, benzyl alcohol and sodium acetate, dissolve and mix, adjust the pH value to 4.0 with acetic acid, then add carbetocin, Stir at 80rpm for 40min at 50°C, dissolve and mix well, then cool to 25°C and add wate...

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Abstract

The invention belongs to the technical field of medicines and relates to a carbetocin injection. The injection is prepared from carbetocin, a polyuronic acid derivative, vitamin D and injection water.In each 2mL of the carbetocin injection, the amount of the carbetocin is 50 to 80mug, the amount of the polyuronic acid derivative is 5 to 8mg and the amount of the vitamin D is 1 to 5mg.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a carbetocin injection. Background technique [0002] In the process of livestock production, improving production efficiency and reducing production costs are the goals that the breeding industry has been pursuing. Birth is an important part of the breeding process of livestock. In the modern breeding mode, there are common problems such as incapable delivery of female animals, long labor process, and postpartum hemorrhage. Serious economic losses will affect the development of animal husbandry. Scientifically and rationally managing the delivery of livestock can greatly improve the breeding efficiency of livestock, prevent the death of livestock during delivery, and thus improve the production capacity of the entire livestock farm. [0003] Prolonged delivery of livestock can lead to severe pain, fatigue, and even physical exhaustion in the female animal. During childbirth, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/11A61K31/59A61K31/732A61K9/08A61P15/04A61P7/04
CPCA61K9/0019A61K9/08A61K31/59A61K31/732A61K47/12A61P7/04A61P15/04A61K2300/00
Inventor 包汝泼翁士乔李开刚舒佳妮姚珍珍
Owner NINGBO SANSHENG BIOLOGICAL TECH CO LTD
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