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siRNA of targeted long-chain noncoding RNA DDX11-AS1 and applications thereof in liver cancer treatment

An RNADDX11-AS1, long-chain non-coding technology, applied in the field of biomedicine, to achieve the effects of inducing apoptosis of liver cancer cells, inhibiting proliferation, significant application prospects and economic value

Active Publication Date: 2018-09-18
XI AN JIAOTONG UNIV
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Problems solved by technology

At present, hepatocellular carcinoma (HCC) is the main type of primary liver cancer, accounting for about 90% of primary liver cancer. Whether DDX11-AS1 is involved in the occurrence and development of liver cancer and serves as a potential therapeutic target for HCC is currently unknown. experimental evidence

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  • siRNA of targeted long-chain noncoding RNA DDX11-AS1 and applications thereof in liver cancer treatment
  • siRNA of targeted long-chain noncoding RNA DDX11-AS1 and applications thereof in liver cancer treatment
  • siRNA of targeted long-chain noncoding RNA DDX11-AS1 and applications thereof in liver cancer treatment

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Embodiment Construction

[0026] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments.

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Abstract

The invention discloses an siRNA of a targeted long-chain noncoding RNA DDX11-AS1 and applications thereof in liver cancer treatment. Through designing and synthesizing the siRNA of the DDX11-AS1 andtransfecting a liver cancer cell line with the siRNA, it is proved that the siRNA can targetedly inhibit expression of the DDX11-AS1, can significantly suppress liver cancer cell proliferation, invasion and migration and can induce liver cancer cell apoptosis. A novel target point for research and development of a liver cancer treatment medicine is provided.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a small interfering RNA (Small interfering RNA, siRNA) targeting long-chain non-coding RNA DDX11-AS1 and its application in the treatment of liver cancer. Background technique [0002] Liver cancer is one of the most common malignant tumors in the world, especially in East Asia, Africa and Southern Europe, and the global incidence rate is increasing year by year. Due to the insidious onset of liver cancer, the difficulty of early diagnosis, the high rate of recurrence and metastasis after treatment, and the poor prognosis, the mortality rate of liver cancer remains high. At present, early surgical resection is the main and most effective treatment for liver cancer, but most patients have advanced liver cancer when they are first diagnosed, which greatly limits surgical treatment. In addition, even for early-stage patients who have successfully undergone surgical resection,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/6886A61K48/00A61K31/713A61P35/00
CPCA61K31/713A61P35/00C12N15/1135C12N2310/14C12Q1/6886
Inventor 孙晋李宗芳孔光耀杨军郭瑛田红卫李君
Owner XI AN JIAOTONG UNIV
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