Method for extracting levodopa by taking mucuna cochinchine-sis(Lour)Tang et Wang as raw material

Abstract

The invention discloses a method for extracting levodopa by taking mucuna cochinchine-sis(Lour)Tang et Wang as a raw material. The method comprises the following steps: (1) raw material pretreatment,(2) extraction, (3) impurity removal, (4) concentration, (5) purification, (6) recrystallization, and (7) drying to obtain a product. According to the method for extracting the levodopa from the mucuna cochinchine-sis(Lour)Tang et Wang as the raw material, an acid solution adopts a mixed acid prepared from formic acid and hydrochloric acid according to a volume ratio of 1:(1 to 3), and can converttyrosine into dopa, thus greatly reducing the content of the tyrosine in the product, and improving the quality of the product; resin is not needed in a preparation process, and generated sewage andwastewater are less and easy to treat. The finished levodopa prepared by the method is high in yield, the crude product yield is 4.0-4.5 percent, the product yield is 2.8-3.0 percent, and the contentof the tyrosine in the prepared finished levodopa is reduced to 0.08 to 0.15 percent, and is reduced by 2 to 5 times compared with levodopa produced according to a conventional process.

Description

technical field [0001] The invention relates to the technical field of agricultural product processing, in particular to a method for extracting levodopa from cat beans. Background technique [0002] Cat bean, Latin scientific name Mucuna cochinchine-sis (Lour) Tang et Wang, also known as Li bean, dragon's claw bean, tiger's claw bean, dog's claw bean, cat's cat bean, leguminous bean is an annual herbaceous vine. Cylindrical stem, vines 2-10m long, multi-branched, three compound leaves, oblong-oval leaflets, racemes, butterfly-shaped corolla, nearly white or purple, is a drought-tolerant and adaptable crop , There are many rhizobia in the root, which can improve the fertility of the soil, the root system is relatively developed, the leaves and tendrils climb high, and the coverage is wide, which is conducive to maintaining water and soil. Native to southern and eastern Asia, China is mainly distributed in South China, Southwest China and Jiangxi, Hunan, Guangxi and other pr...

AI Technical Summary

Problems solved by technology

[0012] Each of the above technologies has its own advantages and disadvantages. Generally speaking, the technology of extracting levodopa from cat beans still has a lot of room for improvement

Some have high anti-corrosion requirements for equipment, short service life of equipment, high depreciation rate, some products produced are not high in purity, quality is not good enough, there are many impurities, product yield is low, product content is low, etc.; It takes a long time, and a large amount of inorganic salts and other substances are added in the preparation process, which may easily cause the heavy metals in the product to exceed the standard and affect the quality of the product; there are also a large amount of high-concentration COD, which makes sewage treatment difficult and expensive.

Although the membrane technology has solved the environmental pollution problem in the traditional acid water-resin method, the cost of the membrane technology is very high. It will quickly clog, reduce the permeation rate, and cause irreversible changes in the permeation flow and separation characteristics of the membrane. Frequent membrane replacement is required to make the cost higher

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