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Method for preparing phospholipid deacylation product

A technology of acyl, glycerol phosphatidylcholine, which is applied in the field of preparation of phospholipid deacyl, can solve the problems of low yield and complex process of glycerol phosphatidylcholine, and achieve simple process, broaden deep processing technology, and short time Effect

Inactive Publication Date: 2018-09-11
YULIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing phospholipid deacylation, which solves the problems of complex process and low yield in the preparation of glycerol phosphatidylcholine in the prior art

Method used

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Examples

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preparation example Construction

[0030] The present invention provides a kind of preparation method of phospholipid deacyl substance, comprises the following steps:

[0031] Step (1): Heat the methanol solution of crude lecithin extracted from bean dregs to 20°C-60°C; add a catalyst to the heated methanol solution of crude lecithin, wherein each liter of crude lecithin Add 25ml-300ml of catalyst; and stir to carry out the reaction, and the reaction time is 0.5h-8h. Here, optionally, the methanol solution of crude lecithin extracted from bean dregs is heated and stirred by using a heat-collecting constant temperature heating magnetic stirrer.

[0032] Step (2): performing rotary evaporation on the reacted mixture obtained in step (1) to obtain an oily product;

[0033] Step (3): vacuum-drying the oily product to obtain a phospholipid deacyl product mainly composed of glycerol phosphatidylcholine.

[0034] Preferably, between step (2) and step (3), it also includes: dissolving the oily product obtained in ste...

Embodiment 1

[0046] This embodiment includes the following steps:

[0047] 1. Extract crude lecithin methanol solution from bean dregs:

[0048] 1.1. Pretreatment of the bean dregs: suction filter the wet bean dregs, rinse the filtered bean dregs with methanol, and then dry the rinsed bean dregs;

[0049] 1.2. Take 6g of pretreated dry bean dregs, grind them, put them into a round-bottomed flask, add 90mL of methanol, and carry out extraction reaction on a constant temperature shaker. The reaction temperature is 40°C, and the reaction time is 4 hours.

[0050] 1.3. Suction filter the reacted mixed solution, and further centrifuge to obtain a methanol solution of crude lecithin with a phosphatidylcholine content of 21%.

[0051]2. Add 60 mL of methanol solution of crude lecithin to a three-necked flask with condensing reflux, place in a constant temperature water bath and heat to 50°C, then add 2 mL of methanol solution of choline hydroxide and butylamine as a catalyst, wherein The concen...

Embodiment 2

[0055] This embodiment includes the following steps:

[0056] 1. Extract crude lecithin methanol solution from bean dregs:

[0057] 1.1. Pretreatment of the bean dregs: suction filter the wet bean dregs, rinse the filtered bean dregs with methanol, and then dry the rinsed bean dregs;

[0058] 1.2. Take 6g of pretreated dry bean dregs, grind them, put them into a round-bottomed flask, add 90mL of methanol, and carry out extraction reaction on a constant temperature shaker. The reaction temperature is 40°C, and the reaction time is 4 hours.

[0059] 1.3. Suction filter the reacted mixed solution, and further centrifuge to obtain a methanol solution of crude lecithin with a phosphatidylcholine content of 21%.

[0060] 2. Add 60mL of methanol solution of crude lecithin to a three-necked flask with condensing reflux, place it in a collector-type constant temperature heating magnetic stirrer and heat it to 60°C, then add 2mL of methanol solution of choline hydroxide and butylamine ...

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Abstract

The invention discloses a method for preparing a phospholipid deacylation product. The method comprises the following steps: heating a methanol solution of crude lecithin extracted from bean dregs to20-60 DEG C; adding a catalyst to the heated methanol solution of crude lecithin according to a ratio of (25-30) ml: 1 L; stirring and reacting the obtained solution; performing rotary evaporation treatment on a mixed solution obtained after the reaction to obtain an oily product; and performing vacuum drying on the oily product to obtain the phospholipid deacylation product based on L-alpha glycerylphosphorylcholine. The method solves the problems of complexity and low yield of an L-alpha glycerylphosphorylcholine preparation technology in the prior art, and has the advantages of concisenessand high efficiency in preparation of the phospholipid deacylation product based on L-alpha glycerylphosphorylcholine, and low cost.

Description

technical field [0001] The invention relates to the technical field of phospholipid deep processing, in particular to a method for preparing a deacyl phospholipid. Background technique [0002] Glycerophosphocholine (GPC for short) is a unique natural water-soluble phospholipid that exists in the human body. It has positive effects on the brain, liver, and kidneys of the human body. Years of experimental research and clinical application have shown that GPC and other natural phospholipid deacylated substances (such as glycerol phosphatidylethanolamine GPE) can not only improve people's memory and cognitive ability, but also have medical effects such as resistance to muscle atrophy and anti-aging. It can be said that It is an anti-aging nutrient for the brain. GPC is a natural protective agent for many organs of the human body, such as the brain, liver, kidney, etc. It is concentrated in the human brain and can prevent stroke, Alzheimer's disease, schizophrenia, and bipolar ...

Claims

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Application Information

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IPC IPC(8): C07F9/09C07F9/10
CPCC07F9/091C07F9/103
Inventor 李红亚严彪
Owner YULIN UNIV
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