A natural hypoglycemic agent that can improve bioavailability and avoid hyperchloremia
A hyperchloremia and utilization technology, applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., can solve problems such as hyperchloremia, unfavorable control of diabetic patients' condition, electrolyte metabolism disorder, etc.
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Embodiment 1
[0030]1. Extraction and purification of berberine hydrochloride in Cortex Phellodendri: Crush the dried Cortex Cortex into coarse powder, and reflux extraction with 4 times the amount of 70% ethanol twice, 2 hours each time. Filtrate with suction, combine the filtrates, and concentrate with a vacuum film at 50°C until there is no alcohol smell. Add 38% concentrated hydrochloric acid to adjust the pH value to 4 until berberine hydrochloride precipitates out. Use 80% ethanol to recrystallize berberine hydrochloride to obtain yellow needle crystals, namely berberine hydrochloride.
[0031] 2. Preparation and purification of berberine organic acid salts (fumarate and citrate): take berberine hydrochloride and citric acid at a mass ratio of 1:2, and dissolve them in distilled water respectively. The ratio is 1:45, the ratio of citric acid to water is 1:5, and dissolved by heating in a water bath at 80°C. The citric acid aqueous solution was slowly added to the berberine hydrochlo...
Embodiment 2
[0037] 1. Extraction and purification of berberine hydrochloride from Cortex Phellodendri: Crush the dried Cortex Phellodendri into coarse powder, and reflux extraction with 6 times the amount of 60% ethanol for 3 times, 1.5 h each time. Filtrate with suction, combine the filtrates, and concentrate with a vacuum film at 50°C until there is no alcohol smell. Add 38% concentrated hydrochloric acid to adjust the pH value to 3 until berberine hydrochloride precipitates out. Use 80% ethanol to recrystallize berberine hydrochloride to obtain yellow needle crystals, namely berberine hydrochloride.
[0038] 2. Preparation and purification of berberine organic acid salts (fumarate and citrate): take berberine hydrochloride and citric acid at a mass ratio of 1:2, and dissolve them in distilled water respectively. The ratio is 1:50, the ratio of citric acid to water is 1:6, and dissolved by heating in a water bath at 80°C. The citric acid aqueous solution was slowly added to the berber...
Embodiment 3
[0044] 1. Extraction and purification of berberine hydrochloride in Cortex Phellodendri: Crush the dried Cortex Cortex into coarse powder, and reflux extraction with 5 times the amount of 80% ethanol for 3 times, each time for 1.5h. Filtrate with suction, combine the filtrates, and concentrate with a vacuum film at 50°C until there is no alcohol smell. Add 38% concentrated hydrochloric acid to adjust the pH value to 4 until berberine hydrochloride precipitates out. Use 85% ethanol to recrystallize berberine hydrochloride to obtain yellow needle crystals, namely berberine hydrochloride.
[0045] 2. Preparation and purification of berberine organic acid salts (fumarate and citrate): take berberine hydrochloride and citric acid at a mass ratio of 1: 2.5, dissolve them in distilled water respectively, and the mixture of berberine hydrochloride and water The ratio is 1:50, the ratio of citric acid to water is 1:6, and dissolved by heating in a water bath at 75°C. The citric acid ...
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