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A natural hypoglycemic agent that can improve bioavailability and avoid hyperchloremia

A hyperchloremia and utilization technology, applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., can solve problems such as hyperchloremia, unfavorable control of diabetic patients' condition, electrolyte metabolism disorder, etc.

Active Publication Date: 2021-05-11
诸暨祥德纺织品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, for type 2 diabetic patients whose own metabolism is already in a state of disorder, continuous and large intake of hydrochloride during the long or even life-long process of blood sugar control is likely to cause electrolyte metabolism disorder and cause hyperchloremia. Hyperemia, which is not conducive to the control of the condition of diabetic patients

Method used

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  • A natural hypoglycemic agent that can improve bioavailability and avoid hyperchloremia
  • A natural hypoglycemic agent that can improve bioavailability and avoid hyperchloremia
  • A natural hypoglycemic agent that can improve bioavailability and avoid hyperchloremia

Examples

Experimental program
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Effect test

Embodiment 1

[0030]1. Extraction and purification of berberine hydrochloride in Cortex Phellodendri: Crush the dried Cortex Cortex into coarse powder, and reflux extraction with 4 times the amount of 70% ethanol twice, 2 hours each time. Filtrate with suction, combine the filtrates, and concentrate with a vacuum film at 50°C until there is no alcohol smell. Add 38% concentrated hydrochloric acid to adjust the pH value to 4 until berberine hydrochloride precipitates out. Use 80% ethanol to recrystallize berberine hydrochloride to obtain yellow needle crystals, namely berberine hydrochloride.

[0031] 2. Preparation and purification of berberine organic acid salts (fumarate and citrate): take berberine hydrochloride and citric acid at a mass ratio of 1:2, and dissolve them in distilled water respectively. The ratio is 1:45, the ratio of citric acid to water is 1:5, and dissolved by heating in a water bath at 80°C. The citric acid aqueous solution was slowly added to the berberine hydrochlo...

Embodiment 2

[0037] 1. Extraction and purification of berberine hydrochloride from Cortex Phellodendri: Crush the dried Cortex Phellodendri into coarse powder, and reflux extraction with 6 times the amount of 60% ethanol for 3 times, 1.5 h each time. Filtrate with suction, combine the filtrates, and concentrate with a vacuum film at 50°C until there is no alcohol smell. Add 38% concentrated hydrochloric acid to adjust the pH value to 3 until berberine hydrochloride precipitates out. Use 80% ethanol to recrystallize berberine hydrochloride to obtain yellow needle crystals, namely berberine hydrochloride.

[0038] 2. Preparation and purification of berberine organic acid salts (fumarate and citrate): take berberine hydrochloride and citric acid at a mass ratio of 1:2, and dissolve them in distilled water respectively. The ratio is 1:50, the ratio of citric acid to water is 1:6, and dissolved by heating in a water bath at 80°C. The citric acid aqueous solution was slowly added to the berber...

Embodiment 3

[0044] 1. Extraction and purification of berberine hydrochloride in Cortex Phellodendri: Crush the dried Cortex Cortex into coarse powder, and reflux extraction with 5 times the amount of 80% ethanol for 3 times, each time for 1.5h. Filtrate with suction, combine the filtrates, and concentrate with a vacuum film at 50°C until there is no alcohol smell. Add 38% concentrated hydrochloric acid to adjust the pH value to 4 until berberine hydrochloride precipitates out. Use 85% ethanol to recrystallize berberine hydrochloride to obtain yellow needle crystals, namely berberine hydrochloride.

[0045] 2. Preparation and purification of berberine organic acid salts (fumarate and citrate): take berberine hydrochloride and citric acid at a mass ratio of 1: 2.5, dissolve them in distilled water respectively, and the mixture of berberine hydrochloride and water The ratio is 1:50, the ratio of citric acid to water is 1:6, and dissolved by heating in a water bath at 75°C. The citric acid ...

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Abstract

A natural hypoglycemic agent capable of improving bioavailability and avoiding hyperchloremia belongs to the technical field of hypoglycemic agents. From berberine fumarate, berberine citrate, total anthraquinone glycosides of rhubarb, total flavonoids of scutellaria baicalensis, hemp seed fat oil according to weight ratio 30‑50:30‑50:3‑5:6‑15: Mixed in a ratio of 1‑3. The above-mentioned natural hypoglycemic agent that can improve bioavailability and avoid hyperchloremia avoids hyperchloremia caused by using berberine hydrochloride as a hypoglycemic agent, through the regulation of intestinal flora and the coordination of molecular pathways It can improve metabolism, greatly improve oral bioavailability and hypoglycemic effect; the raw material is pure natural source, the hypoglycemic effect is remarkable, stable and long-lasting, green and safe, and has no toxic and side effects; after clinical application, chronic diabetic patients stop using western medicine Hypoglycemic drugs, insist on taking the product for more than 1 year, blood sugar and other indicators are normal and stable.

Description

technical field [0001] The invention belongs to the technical field of hypoglycemic agents, in particular to a natural hypoglycemic agent capable of improving bioavailability and avoiding hyperchloremia. Background technique [0002] With the acceleration of population aging and changes in people's lifestyles, diabetic patients are increasing day by day. According to preliminary statistics, the number of adult diabetic patients worldwide is expected to account for 5.4% of the world's population by 2025. And related complications, causing harm to health and seriously affecting the quality of life of patients. Therefore, it is of great significance to find safe and effective drugs for lowering blood sugar and preventing and treating diabetic complications in natural medicines. [0003] Berberine, also known as berberine, is a common isoquinoline alkaloid mainly found in Coptis chinensis, Cortex Phellodendron, and Sanke needles in Ranunculaceae plants. Berberine hydrochlorid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61P3/10A61K31/4375
CPCA61K31/4375A61K36/539A61K36/60A61K36/708A61K2236/31A61K2236/333A61K2236/39A61K2236/55A61P3/10A61K2300/00
Inventor 袁珂李静婉罗阳方继莉
Owner 诸暨祥德纺织品有限公司
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