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Application of diflunisal in preparation of drug for preventing and treating diabetes

A diabetes drug, the technology of diflunisal, which is applied in the field of medicine, can solve the problems of anti-diabetic effects such as no reports, and achieve remarkable effects, increase absorption, and improve the effect of the disease

Inactive Publication Date: 2018-09-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the antidiabetic effect of diflunisal’s monomeric components

Method used

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  • Application of diflunisal in preparation of drug for preventing and treating diabetes
  • Application of diflunisal in preparation of drug for preventing and treating diabetes
  • Application of diflunisal in preparation of drug for preventing and treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Cell culture

[0031] BNL CL.2 (mouse embryonic liver) cells were cultured in low-sugar DMEM medium containing 10% FBS and 1% double antibody, and placed in a cell culture incubator. When the cells grew to 90% confluent, 0.25% Digest with trypsin-EDTA solution; add three times the amount of culture medium to stop digestion, centrifuge the cell solution at 900r / min for 5min, discard the supernatant, add a certain amount of culture medium, blow the cells away, take 10μL and count, BNL CL.2 cells Seed in a 96-well plate with 10,000 cells per well, and set a cell-free blank control well; after 36 hours of culture, discard the original medium and replace it with low-sugar DMEM medium without serum and phenol red, and add the test drug in groups.

[0032] 2. Grouping

[0033] Set blank control group (add 100 μL of normal cell culture medium), model group (add 100 μL of cell culture medium containing 1 μM insulin), diflunisal-20 μM group (add cell culture medium containing...

Embodiment 2

[0039] Preparation of Diflunisal Tablets

[0040]

[0041] Preparation process: Diflunisal, microcrystalline cellulose and low-substituted methylcellulose in the prescription are passed through an 80-mesh sieve, and the prescription amount of diflunisal is mixed with microcrystalline cellulose and low-substituted methylcellulose Uniformly add 2% hydroxypropyl methylcellulose solution to granulate in an appropriate amount, dry, granulate, add prescription amount of magnesium stearate, mix evenly, and compress into tablets to obtain 400 tablets.

Embodiment 3

[0043] Preparation of Diflunisal Tablets

[0044]

[0045] Preparation process: pass diflunisal, microcrystalline cellulose and low-substituted methylcellulose in the prescription through an 80-mesh sieve, weigh the prescription amount of diflunisal, microcrystalline cellulose and low-substituted methylcellulose and mix evenly , add 2% hydroxypropyl methylcellulose solution to granulate in an appropriate amount, dry, granulate, add the prescribed amount of magnesium stearate, mix evenly, and compress into tablets to obtain 400 tablets.

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Abstract

The invention aims to provide application of diflunisal in preparation of a drug for preventing and treating diabetes. The diflunisal is used as an effective component in the drug for preventing and treating the diabetes. The concentration of the diflunisal in the drug for preventing and treating the diabetes is 40 to 80 [mu]M. The diflunisal can be well applied to the drug for preventing and treating the diabetes, particularly type II diabetes; the diflunisal can obviously improve insulin resistance and improve the absorption of hepatic cells under insulin resistance for glucose; the effect is outstanding; the aim of preventing and improving the diabetic condition is achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of diflunisal in the preparation of drugs for the prevention and treatment of diabetes. Background technique [0002] According to the statistics of the International Diabetes Federation (IDF), there were more than 400 million people with diabetes in the world in 2017, and it is estimated that by 2045, the number of people with diabetes worldwide will reach about 700 million. Data show that in 2013, the prevalence of diabetes among adults in my country was 10.9%, and the prevalence of prediabetes was 35.7%. The situation of diabetes prevention and control in my country is still grim (Wang L, et al. Jama, 2017, 317(24): 2515.) . [0003] Diabetes is a chronic complex disease. As the disease progresses, patients develop microvascular and macrovascular lesions, which damage the eyes, heart, kidneys and other organs, and even lead to blindness, heart failure, renal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/603A61P3/10
Inventor 程翼宇王毅杨继鸿
Owner ZHEJIANG UNIV
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