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Biomedical application of 1-deoxy-2,3-dehydronagilactone A serving as UCP2 inhibitor for treating gastric adenocarcinoma

A technology of bamboo cypress lactone, biomedicine, applied in the field of biology

Inactive Publication Date: 2018-09-04
吾建峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there have been no reports that cypress lactone J, 1-deoxy-2,3-dehydrocinematin A, monomonasin A, and monomonasin B can be used as UCP2 inhibitors for the treatment of gastric adenocarcinoma, and there is no report that cypressin Ester J, 1-deoxy-2,3-dehydrolipidolide A, monomonasin A, monomonasin B can be used as lncRNA XLOC006926 inhibitors in the treatment of liver cancer

Method used

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  • Biomedical application of 1-deoxy-2,3-dehydronagilactone A serving as UCP2 inhibitor for treating gastric adenocarcinoma
  • Biomedical application of 1-deoxy-2,3-dehydronagilactone A serving as UCP2 inhibitor for treating gastric adenocarcinoma
  • Biomedical application of 1-deoxy-2,3-dehydronagilactone A serving as UCP2 inhibitor for treating gastric adenocarcinoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: cypress lactone J, 1-deoxy-2,3-dehydro cypress lactone A, monomonasin A, and monomonasin B can be used as UCP2 inhibitors for the treatment of gastric adenocarcinoma

[0034] 1. Experimental materials

[0035] The chemical structural formulas of cypress lactone J, 1-deoxy-2,3-dehydro cypress lactone A, unique monosourdin A, and unique monosourdin B are as follows figure 1 shown. These compounds are all purchased or self-made, with a purity of more than 95%, and can be used in cell experiment research.

[0036] Gastric adenocarcinoma cell line SGC7901 was purchased from ATCC; fetal bovine serum and DMEM culture medium were purchased from Gibco, USA.

[0037] UCP2 mouse anti-human monoclonal antibody, β-actin mouse anti-human monoclonal antibody and mouse secondary antibody were purchased from Santa Cruz, USA.

[0038] 2. Experimental method

[0039] 1. Cell culture

[0040] Gastric adenocarcinoma cell line SGC7901 was cultured in DMEM medium containing 10...

Embodiment 2

[0060] Example 2: cypress lactone J, 1-deoxy-2,3-dehydro cypress lactone A, monomonasin A, and monomonasin B can be used as lncRNA XLOC006926 inhibitors to treat liver cancer

[0061] 1. Experimental materials

[0062] The chemical structural formulas of cypress lactone J, 1-deoxy-2,3-dehydro cypress lactone A, unique monosourdin A, and unique monosourdin B are as follows figure 1 shown. These compounds are all purchased or self-made, with a purity of more than 95%, and can be used in cell experiment research.

[0063] The liver cancer cell line HepG2 was purchased from ATCC; fetal bovine serum and DMEM culture medium were purchased from Gibco, USA.

[0064] RT-PCR primers for lncRNA XLOC006926 and GAPDH were designed according to the literature and synthesized outsourced. The sequences are as follows:

[0065] lncRNA XLOC006926 upstream primer: 5'-AAGGAGAACACAAAACAGGCAT-3';

[0066] LncRNA XLOC006926 downstream primer: 5'-TGTGAAGCCCTAGATTTCCCAT-3';

[0067] GAPDH upstrea...

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PUM

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Abstract

The invention discloses biomedical application of 1-deoxy-2,3-dehydronagilactone A serving as a UCP2 inhibitor for treating gastric adenocarcinoma. Nagilactone J, 1-deoxy-2,3-dehydronagilactone A, lamiophlomiol A and lamiophlomiol B serve as effective UCP2 inhibitors, and the nagilactone J, 1-deoxy-2,3-dehydronagilactone A, lamiophlomiol A and lamiophlomiol B can be further used for treating the gastric adenocarcinoma by inhibiting the UCP2 to inhibit proliferation of gastric adenocarcinoma cells.

Description

technical field [0001] The present invention belongs to the field of biology, and relates to the new application of known compounds, in particular to cypress lactone J, 1-deoxy-2,3-dehydro cypress lactone A, monomonadin A, and monomonadin B as UCP2 inhibitors agent for the treatment of gastric adenocarcinoma and biomedical use as lncRNA XLOC006926 inhibitor for the treatment of liver cancer. Background technique [0002] Gastric cancer is the fourth most common malignant tumor in the world. Although the incidence rate has been decreasing in recent years, the mortality rate remains high due to the low rate of early diagnosis. Therefore, it is necessary to look for markers and potential targets to judge the prognosis of gastric cancer. Studies have found that UCP2 (uncoupling protein-2) is a member of the mitochondrial uncoupling protein family, which can uncouple the process of oxidative phosphorylation, reduce the generation of ROS, and have a protective effect on tumor cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/366A61K31/352A61P35/00
CPCA61K31/365A61K31/352A61K31/366A61P35/00
Inventor 吾建峰王志礼
Owner 吾建峰
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