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Drug-carrying modification layer and application thereof in improving material surface biocompatibility

A technology of biocompatibility and modification layer, applied in coating, medical science, prosthesis, etc., can solve problems such as different functions, achieve comprehensive performance improvement, improve biocompatibility, and good stability

Active Publication Date: 2018-08-17
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the functions of HA with different molecular we

Method used

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  • Drug-carrying modification layer and application thereof in improving material surface biocompatibility
  • Drug-carrying modification layer and application thereof in improving material surface biocompatibility
  • Drug-carrying modification layer and application thereof in improving material surface biocompatibility

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0032] Example 1

[0033] Referring to the accompanying drawings, a Chinese medicine-loaded component modification layer for improving its biocompatibility on the surface of Mg-Zn-Mn alloy, and its preparation steps are:

[0034] Preparation of dopamine / hexanediamine / hyaluronic acid composite modified layer on the surface of Mg-Zn-Mn alloy: Dopamine hydrochloride and hexanediamine were dissolved together in Tris buffer with pH 8.0, the concentration of dopamine was 1mg / ml, hexanediamine was The concentration of amine is 4 mg / ml, the material is immersed, and the copolymer is deposited for 12 hours at 37 ° C. After the reaction is completed, the residual reaction solution is removed by suction, the unpolymerized molecules are washed with deionized water, and dried for use; the molecular weight is 1 × 10 4 The hyaluronic acid of DA is dissolved in deionized water to prepare an aqueous solution with a concentration of 1 mg / ml; the traditional Chinese medicine ingredient Ophiopogo...

Example Embodiment

[0035] Embodiment 2

[0036] A Chinese medicine-loaded component modification layer for improving the biocompatibility of the cobalt-chromium alloy surface, the preparation steps of which are:

[0037] Preparation of dopamine / hexanediamine / hyaluronic acid composite modified layer on polished cobalt-chromium alloy surface: Dopamine hydrochloride and hexanediamine were dissolved together in Tris buffer with pH 8.5, the concentration of dopamine was 5mg / ml, hexanediamine The concentration is 20mg / ml, the material is immersed, and the co-polymerization is deposited for 6h at 60 °C. After the reaction is completed, the residual reaction solution is removed by suction, the unpolymerized molecules are washed with deionized water, and dried for use; the molecular weight is 1 × 10 6 The hyaluronic acid of DA is dissolved in deionized water to prepare an aqueous solution with a concentration of 2 mg / ml; the traditional Chinese medicine ingredient Ophiopogon saponin extract is dissolved ...

Example Embodiment

[0038] Embodiment 3

[0039] A Chinese medicine-loaded component modification layer for improving biocompatibility on the surface of a degradable polylactic acid material, the preparation steps of which are:

[0040] Preparation of dopamine / hexamethylenediamine / hyaluronic acid composite modified layer on the surface of degradable polylactic acid material: Dopamine hydrochloride and hexamethylenediamine were dissolved together in Tris buffer with pH 9.0, the concentration of dopamine was 2mg / ml, hexamethylenediamine The concentration is 10mg / ml, the material is immersed, and the copolymer is deposited for 24h at 25°C. After the reaction is completed, the residual reaction solution is removed by suction, the unpolymerized molecules are washed with deionized water, and dried for use; the molecular weight is 1 × 10 3 The hyaluronic acid of DA is dissolved in deionized water to prepare an aqueous solution with a concentration of 5mg / ml; the traditional Chinese medicine ingredient O...

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Abstract

The invention discloses a drug-carrying modification layer which is covalently connected with a hyaluronic acid dopamine/hexamethylenediamine copolymerization thin film. The modification layer carriesophiopogonin. A biological modification layer having multiple functions of being resistant to coagulation and hyperplasia, inhibiting inflammatory reaction and promoting endothelialization is built on the surface of a material, and biocompatibility of the surface of the material is improved remarkably.

Description

technical field [0001] The invention relates to a drug-loading modified layer. Background technique [0002] The surface modification technology of cardiovascular stent materials has gradually matured and is widely used in clinical practice. However, the surface curative effect of the materials currently used in clinical practice is far from reaching the expected goal. This is mainly due to the symptoms of coagulation, proliferation, inflammation, and delayed endothelialization on the material surface, which can lead to problems such as late thrombus and restenosis after implantation. [0003] By preparing a multifunctional modified layer on the surface of the material, giving the material good biocompatibility is the basis of new technologies for surface modification of the material. [0004] To build a universal functional layer on a variety of different cardiovascular stent materials, it is necessary to select organic molecules that can be combined with a variety of mat...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/28A61L27/54A61L27/50
CPCA61L27/28A61L27/34A61L27/50A61L27/54A61L2300/41A61L2300/412A61L2300/416A61L2300/42A61L2420/02A61L2420/06C08L5/08
Inventor 李敬安张琨关绍康罗霄王利国朱世杰常蕾王俊
Owner ZHENGZHOU UNIV
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