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System and method of diagnosing endothelial dysfunction utilizing circulating miRNAs as biomarkers

A technology for endothelial dysfunction and biomarkers, which is applied in the fields of biochemical equipment and methods, determination/examination of microorganisms, sugar derivatives, etc.

Inactive Publication Date: 2018-07-31
SERENIUM INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A state-of-the-art approach suggests that differential miRNAs in circular exosomes may underlie the bipartite vascular phenotype in children with obesity and OSA

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  • System and method of diagnosing endothelial dysfunction utilizing circulating miRNAs as biomarkers
  • System and method of diagnosing endothelial dysfunction utilizing circulating miRNAs as biomarkers
  • System and method of diagnosing endothelial dysfunction utilizing circulating miRNAs as biomarkers

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Embodiment Construction

[0011] The present invention has specific implementations in different forms, which will be described in detail with reference to the accompanying drawings. Any specific implementation based on the technical solution disclosed in the present invention and its inventive concept shall be an example of the principle of the present invention. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0012] It can be understood that those skilled in the art can make improvements or transformations according to the description of the preferred embodiments of the present invention, and all these improvements and transformations should belong to the protection scope of the appended claims of the present invention.

[0013] subjects

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Abstract

The invention discloses a system and method of diagnosing endothelial dysfunction utilizing circulating miRNAs as biomarkers. It was determined that plasma-derived exosomes from either obese (OB) or obstructive sleep apnea (OSA) children with evidence of endothelial dysfunction (ED). Such ED exosomes lead to up-regulation of adhesion molecules in endothelial cells. Exosomal miRNA cargo differencesunderlie the mechanisms accounting for the presence of ED. Specifically, expression of miRNA-630 is reduced in circulating exosomes of either obese or OSA children with ED, and normalizes in OSA children with ED after treatment along with restoration of endothelial function. These findings elucidate a novel role of exosomal rniRNA-630 as a putative key mediator of vascular function and a biomarker of cardiovascular disease (CVD) risk in children.

Description

technical field [0001] The invention relates to a system and method for diagnosing endothelial dysfunction, in particular to a system and method for diagnosing endothelial dysfunction using circular RNA as a biomarker. Background technique [0002] Obese children are at increased risk of obstructive sleep apnea. These two conditions are closely related to endothelial dysfunction (ED), which is an early risk factor for cardiovascular disease in children. Although weight loss and treatment of OSA improve endothelial function, not every child with obesity or OSA develops ED. Nano-sized membrane vesicle exosomes are commonly found in plasma, which contain functional mRNA and miRNA that can be transported to endothelial cells and other cells. A prior art approach suggests that differential miRNAs in circular exosomes may underlie the bipartite vascular phenotype in children with obesity and OSA. [0003] The method of the present invention focuses on plasma exosomes from obese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/53C07H21/04
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 大卫·格扎尔利拉·格扎尔
Owner SERENIUM INC
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