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Rhizoma bletillae polysaccharose and extraction method thereof

A technology of polysaccharides and extracts, applied in the field of biopharmaceuticals, can solve the problems of difficult post-processing, etc., and achieve the effects of improving input efficiency, saving energy efficiency, and simplifying the effectiveness of separation

Active Publication Date: 2018-07-27
北京颐方生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention also solves the problem that the post-treatment process becomes not easy due to the viscosity of white and polysaccharides during the extraction process.

Method used

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  • Rhizoma bletillae polysaccharose and extraction method thereof
  • Rhizoma bletillae polysaccharose and extraction method thereof
  • Rhizoma bletillae polysaccharose and extraction method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] This embodiment provides a method for extracting white and polysaccharides from white and white, including the following steps:

[0055] 1) Slice the collected fresh white and rhizomes into a volume of 0.1×0.1×0.1cm 3 Specification: take 10Kg and place it in liquid nitrogen for 1 min, then place the sliced ​​particles in 30L of dry ice / ethanol solution, sonicate and smash for 0.1 min, place the pulverized solution at room temperature and stir for 12 hours, then take the white and particles;

[0056] 2) Carry out continuous dynamic countercurrent extraction of the white and white particles obtained in step 1). Use 10Kg / h white and 80L / h water for dynamic counter-current extraction. Keep the temperature of the ultrasonic extraction tube at 60℃ and extract for 40 minutes to obtain white and white particles. Polysaccharide extract; input the extract into the liquid residue squeezing separation device to separate the filter residue to obtain the extract of white and polysaccharide...

Embodiment 2

[0063] This embodiment provides a method for extracting white and polysaccharides from white and white, including the following steps:

[0064] 1) Slice the collected fresh white and rhizome into a volume of 0.8×0.8×0.3cm 3 Specification, take 13Kg and place it in liquid nitrogen for 2 minutes, then place the slices in 50L of dry ice / ethanol / acetone solution (the volume ratio of ethanol and acetone is 3:7), ultrasonically shake and crush for 10 minutes, and place the crushed solution at room temperature After stirring for 18 hours, take white and granules;

[0065] 2) Carry out continuous dynamic countercurrent extraction of the white and white particles obtained in step 1). Use 13Kg / h white and 100L / h 1% brine for dynamic countercurrent extraction. Keep the temperature of the ultrasonic extraction tube at 65°C and extract for 45 minutes. The extract of white and polysaccharide; the extract is fed into the liquid residue squeezing and separating device, the filter residue is separa...

Embodiment 3

[0072] This embodiment provides a method for extracting white and polysaccharides from white and white, including the following steps:

[0073] 1) Slice the collected fresh white and rhizome into a volume of 1.5×1.5×0.8cm 3 Specifications, take 18Kg and put it in liquid nitrogen for 4min, then place the slices in 80L of dry ice / ethanol / acetone solution (the volume ratio of ethanol and acetone is 7:3), ultrasonically shake and crush for 20min, and place the crushed solution at room temperature After stirring for 24 hours, take white and granules;

[0074] 2) Carry out continuous dynamic countercurrent extraction of the white and white particles obtained in step 1), enter the equipment at the speed of 18Kg / h white and 3% salt water at 170L / h for dynamic countercurrent extraction, and keep the ultrasonic extraction tube temperature at 70℃ , Extract for 55 minutes to obtain an extract containing white and polysaccharides; input the extract into the liquid residue squeezing separation d...

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Abstract

The invention relates to the technical field of biopharmacy, and relates to an extraction method of a medical material, in particular to rhizoma bletillae polysaccharose and an extraction method thereof. The method comprises the following steps of (1) before extraction, performing ultrasonic concussion crushing on rhizoma bletillae in the freezing state to obtain rhizoma bletillae solid particles;(2) performing continuous dynamic reverse flow extraction on the obtained rhizoma bletillae particles to obtain extraction solution; (3) performing purification and crystallization on the extractionliquid to obtain rhizoma bletillae polysaccharose. The rhizoma bletillae polysaccharose and the extraction method thereof have the following technical effects that the method is simple; the content ofthe rhizoma bletillae polysaccharose in extracts is improved; the production efficiency is improved; the solvent consumption is reduced; the extraction temperature is reduced; the energy consumptionis reduced; the investment efficiency of the industry is improved; the separation efficiency is simplified; the production efficiency can be improved; the energy efficiency is saved; the purity and the quality of the rhizoma bletillae polysaccharose are ensured. The extraction method has the short process steps; the process is simple; the method is suitable for industrial production.

Description

Technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and relates to a method for extracting medicinal materials, in particular to a white and polysaccharide and an extraction method thereof. Background technique [0002] RhizomaBletillae (RhizomaBletillae) is a plant belonging to the genus Bletillastriata.(Thunb.)Reichb.f., a traditional Chinese medicine with a long history of use. It is the dried tuber of the orchid family Bletillae. The Chinese "Compendium of Materia Medica" records: "Baiji is also known as Lianjicao, licorice, Baigi, and its roots are white, and it grows after being connected, so it is called Baiji. Its tubers can be used as medicine. It was first recorded in "Shen Nong's Materia Medica" and was collected in various places after 1963. One of the Chinese medicine varieties in the version of the Chinese Medicine Pharmacopoeia, Baiji contains a lot of mucilage, which is bitter, astringent, sweet, and slightly cold. It enters ...

Claims

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Application Information

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IPC IPC(8): C08B37/00
CPCC08B37/0003C08B37/006Y02P20/10
Inventor 石清东王姣王正元
Owner 北京颐方生物科技有限公司
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