Application of miRNA708 and/or 301-cluster miRNA in the aspect of improving cardiac function
A tiny, functional technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, cardiovascular system diseases, etc., can solve problems that hinder the development of stem cell therapy
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[0107] After extensive and in-depth research, and through a large number of screenings, the present inventor unexpectedly found for the first time that the microRNAs of miRNA708 and 301 clusters can (i) promote the proliferation of cardiomyocytes; (ii) improve the ability of cardiomyocytes to resist hypoxia; (iii) ) reducing apoptosis and death of cardiomyocytes; (iv) inducing proliferation and differentiation of cardiac stem cells; and / or (v) protecting cardiomyocytes from hypoxic stimulation. On this basis, the inventors have completed the present invention.
[0108] miRNA301, 708 cluster
[0109]miRNA301 and cluster 708 microRNAs are single-stranded RNAs with a length of only 23 bases, which are conserved in mammalian sequences. It has been reported in the literature that both are related to the occurrence and regulation of cancer, and miRNA301 is also related to immune function. However, the regulatory relationship between miRNA301 and 708 cluster microRNAs and heart dev...
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