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Application of oroxylin A or pharmaceutically acceptable salt and solvate of oroxylin A

A technology of melaleucain and solvate, which is applied in the biological field, can solve the problems of high fatality rate, achieve the effects of saving resources, good drug efficacy and application prospects, and shortening the research and development cycle

Inactive Publication Date: 2018-07-24
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the incidence of AHS is only 0.1%, the fatality rate is as high as 20%.

Method used

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  • Application of oroxylin A or pharmaceutically acceptable salt and solvate of oroxylin A

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 verifies the effect of phyllothin A on inhibiting xanthine oxidase activity

[0020] Xanthine Oxidase (XO, EC 1.17.3.2) is a highly specific enzyme that can not only catalyze hypoxanthine to xanthine, and then uric acid, but also directly catalyze xanthine to uric acid. This example proves that kelp A has the activity of inhibiting xanthine oxidase and can be used to prevent or treat hyperuricemia.

[0021] Allopurinol is a urate-lowering drug widely used at present. Allopurinol is a competitive xanthine oxidase inhibitor, which produces urate-lowering effect by inhibiting uric acid synthesis. In this example, allopurinol was used as a control to verify the effect of safflower paper A on inhibiting xanthine oxidase.

[0022] (1) Preparation of phosphate buffer solution (PBS)

[0023] Phosphate buffer preparation pH=7.4, 50mM, prepared according to the appendix of "Pharmacopoeia of the People's Republic of China" 2015 edition, the specific preparation method...

Embodiment 2

[0056] Example 2 Verification of the effect of uric acid-lowering activity of melaleucain A

[0057] In this example, allopurinol was used as a model control to verify the effect of uric acid-lowering activity of melaleucain A.

[0058] (1) Weigh an appropriate amount of potassium oxonate, suspend it with 0.5% CMC-Na solution, and prepare a 12.5 mg / mL modeling solution.

[0059] CMC-Na (sodium carboxymethyl cellulose) is a cellulose salt obtained after chemical modification of natural cellulose, and is a carboxymethyl etherification product of cellulose.

[0060] (2) Take 60 test mice (Kunming mice, male mice) and randomly divide them into 6 groups according to body weight, 10 in each group, and set them as blank control group, model control group, allopurinol group, thousand Papyrin A high-dose group, paper paper A middle-dose group and Paper paper low-dose group paper paper;

[0061] On the 1st-5th day, the above-mentioned test mice were kept in separate cages indoors, at ...

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Abstract

The invention belongs to the technical field of biology, relates to application of oroxylin A or pharmaceutically acceptable salt and a solvate of oroxylin A, and particularly relates to the application of the oroxylin A or pharmaceutically acceptable salt and solvate of the oroxylin A in preparation of a medicine for preventing and / or treating hyperuricemia. The oroxylin A has a good inhibition effect on xanthine oxidase, has a good effect of reducing activity of uric acid; the oroxylin A as a new medicine for treating the hyperuricemia or gout has a good medicine effect and application prospect.

Description

technical field [0001] The present invention belongs to the field of biotechnology, and more specifically relates to the application of kellin A or its pharmaceutically acceptable salt and solvate. Background technique [0002] With the improvement of people's living standards and changes in eating habits, the incidence of hyperuricemia and gout in my country has been increasing year by year in recent years. Hyperuricemia is a disease in which blood uric acid exceeds the normal value due to purine metabolism disorder and / or uric acid excretion disorder. It refers to the level of blood uric acid on an empty stomach twice on different days under a normal purine diet: male > 420 μmol / L, Women >360μmol / L, no clinical symptoms. When the human body is in the condition of hyperuricemia for a long time, uric acid is precipitated in the joints, soft tissues, cartilage and kidneys in the form of sodium salt, causing human organ and tissue lesions, leading to gout, and causing s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P19/06
CPCA61K31/352
Inventor 赵玲杨博
Owner WUHAN POLYTECHNIC UNIVERSITY
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