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Porous silicon-coated graphene nano-sustained-release drug-carrying system and its preparation method and application, as well as loaded drug and its preparation

A nano-sustained release and graphene technology, applied in the field of materials, can solve the problems of difficult large-scale product production and preparation, difficulty, cumbersome steps, etc., and achieve the effect of simple steps, good use safety, and simple operation process

Active Publication Date: 2020-05-22
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the biological toxicity of CTAB as a template, and the cumbersome steps to remove CTAB in mesopores, it is difficult to popularize and apply this method, and it is also difficult to realize the production and preparation of large-scale products.

Method used

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  • Porous silicon-coated graphene nano-sustained-release drug-carrying system and its preparation method and application, as well as loaded drug and its preparation
  • Porous silicon-coated graphene nano-sustained-release drug-carrying system and its preparation method and application, as well as loaded drug and its preparation
  • Porous silicon-coated graphene nano-sustained-release drug-carrying system and its preparation method and application, as well as loaded drug and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Take 0.2g of micron-sized single-layer graphene oxide, add it to 100ml of deionized water, and place it in an ultrasonic pulverizer under ice bath conditions, and ultrasonically treat it for 1 hour to obtain a nanometer graphene oxide aqueous dispersion with a size of about 200 nanometers;

[0065] According to the mass ratio of 1:1, measure an appropriate amount of nano-graphene oxide aqueous dispersion, mix it with an appropriate amount of PVP k30, and ultrasonically treat it for 30 minutes to obtain nGO-PVP;

[0066] Then, the STOBER growth method was used to coat SiO on the surface of nano-graphene oxide. 2 , that is, 50ml ethanol, 10mgGO-PVP, 5ml ammonia water and 2ml TOES were mixed and reacted at 25°C for 3h; then, the product system was centrifuged at 12000r / min for 20min, the supernatant was removed, and the precipitate was recovered, which was nGO -PVP@SiO 2 , that is, the outer surface is SiO 2 The structure of the coated nGO-PVP was detected by scanning el...

Embodiment 2

[0072] Take 0.5g of micron-sized single-layer graphene oxide, add it to 100ml of deionized water, and place it in an ultrasonic pulverizer under ice bath conditions, and ultrasonically treat it for 45 minutes to obtain a nanometer graphene oxide aqueous dispersion with a size of about 200 nanometers;

[0073] According to the mass ratio of 1:2, measure an appropriate amount of nano-graphene oxide aqueous dispersion, mix it with an appropriate amount of PVP k30, and ultrasonically treat it for 30 minutes to obtain nGO-PVP;

[0074] Mix 100ml of ethanol, 20mg of GO-PVP, 10ml of ammonia water and 5ml of TOES at 30°C for 5h; then, centrifuge the product system at 12000r / min for 20min, remove the supernatant, and recover the precipitate, which is nGO -PVP@SiO 2 , that is, the outer surface is SiO 2 Coated nGO-PVP;

[0075] Next, the GO-PVP@SiO 2 Mix with PVP k15 at a mass ratio of 1:2, then reflux at 95°C for 3 hours; then centrifuge the product system at a speed of 12,000r / min ...

Embodiment 3

[0078] Take 0.3g of micron-sized single-layer graphene oxide, add it to 100ml of deionized water, and place it in an ultrasonic pulverizer under ice bath conditions, and ultrasonically treat it for 90 minutes to obtain a nanometer graphene oxide aqueous dispersion with a size of about 200 nanometers;

[0079] According to the mass ratio of 1:3, measure an appropriate amount of nano-graphene oxide aqueous dispersion, mix it with an appropriate amount of PVP k30, and ultrasonically treat it for 30 minutes to obtain nGO-PVP;

[0080] Mix 80ml of ethanol, 15mg of GO-PVP, 10ml of ammonia water and 3ml of TOES at 20°C for 5h; then, centrifuge the product system at 12000r / min for 20min, remove the supernatant, and recover the precipitate, which is nGO -PVP@SiO 2 , that is, the outer surface is SiO 2 Coated nGO-PVP;

[0081] Next, the GO-PVP@SiO 2 Mix with PVP k15 at a mass ratio of 1:3, then reflux at 95°C for 3 hours; then centrifuge the product system at a speed of 12000r / min fo...

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Abstract

The invention provides a porous silicon coated graphene nano slow-release drug carrying system as well as a preparation method and application thereof, and a supported drug and preparation. The preparation method provided by the invention has the advantages of simple operation process and concise steps, does not need complicated aftertreatment and is suitable for large-scale production of a silicon dioxide protection type graphene oxide material. Meanwhile, the porous silicon coated graphene nano slow-release drug carrying system prepared by the preparation method has good drug carrying performance, avoids residue of meso-porous silicon template, and thus can further serve as a carrier for preparing the supported drug; moreover, the system has perfect safety in use.

Description

technical field [0001] The invention relates to the field of materials, in particular, to a porous silicon-coated graphene nano-sustained-release drug-carrying system, a preparation method and application thereof, and a loaded drug and its preparation. Background technique [0002] Graphene oxide (Graphene oxide, GO) is a graphene oxide obtained by chemical oxidation of graphite powder and then ultrasonic exfoliation. 2 A new type of single-layer two-dimensional carbon material composed of hybrid carbon atoms. Because there are a large number of oxygen-containing active functional groups such as carboxyl, hydroxyl, carbonyl, and epoxy on its surface, it has good water solubility and biocompatibility. [0003] In recent years, graphene oxide has become a hotspot in biomedical research, mainly focusing on nano-drug loading, tumor treatment, and photothermal imaging. However, the disadvantage of the current application of graphene is that it has certain biological toxicity. S...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K47/32
CPCA61K47/02A61K47/32
Inventor 滕士勇宋雪松李志文郭子龙李今硕杨文胜
Owner JILIN UNIV
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