An electrochemical gas sensor for joint detection of exhaled nitric oxide and exhaled hydrogen sulfide

Abstract

The invention discloses a four-electrode electrochemical gas sensor capable of measuring both nitric oxide and hydrogen sulfide in expiratory air. A four-electrode system is formed by two working electrodes, one auxiliary electrode, one reference electrode, one hydrogen sulfide filter and an electrolyte. The four-electrode electrochemical gas sensor is characterized in that the two working electrodes are located on the same horizontal plane and are further spatially relatively independent; the two working electrodes are made from the same electrode material; the hydrogen sulfide filter is located above one of the two working electrodes. The shapes of the working electrodes are semicircular; the electrode material is a gold-doped carbon nanotube, graphite or graphene. The gold-doped workingelectrodes are sensitive to the hydrogen sulfide, and can be used for obtaining a hybrid response signal of the nitric oxide and the hydrogen sulfide; however, a response signal of the nitric oxide can be only obtained on the working electrode provided with the hydrogen sulfide filter; in this way, through calculating a difference value, response signals of the nitric oxide and the hydrogen sulfide can be both obtained on the sensor, and the sensor can be used for realizing simultaneously detecting expiratory nitric oxide and expiratory hydrogen sulfide.

Description

technical field [0001] The invention relates to the field of breath detection, in particular to an electrochemical gas sensor capable of simultaneously measuring nitric oxide and hydrogen sulfide in breath. Background technique [0002] Exhaled NO is an internationally recognized marker of eosinophils or allergic airway inflammation, with a normal concentration range of 5-25 ppb, and a variety of commercial products have been used in clinical practice. Recent studies using laboratory instruments have found that exhaled H 2 S may be a marker of neutrophils or infectious airway inflammation, for example, Jack FDummer from the University of Otago found that exhaled H 2 There was a negative correlation between S concentration and sputum neutrophil level, H 2 The S concentration range is around 10 ppb. Therefore, exhaled NO and H 2 The combined detection of S is expected to distinguish the types of inflammation and provide a more effective basis for medication. exhaled NO an...

AI Technical Summary

Problems solved by technology

Among them, the chemiluminescence instrument is expensive, the maintenance method is complicated, and its clinical application is greatly restricted. The electrochemical NO sensor technology of Sweden NIOX and China Sunwell has been widely used in the detection of clinical breath NO

Exhale H 2 The detection of S has not yet been reported on commercial clinical technology, and the detection of exhaled H in the laboratory 2 The detection methods of S are mostly gas chromatography and chemiluminescence, the equipment is expensive and the analysis method is relatively complicated, which is greatly limited in clinical application.

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