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Medicine for reducing blood pressure

A technology for lowering blood pressure and drugs, applied in the field of medicine, can solve the problems of liver metabolic enzyme disorder, lack of protection of target organs, changes in blood biochemical indicators, etc.

Inactive Publication Date: 2018-04-03
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although the traditional antihypertensive drugs currently used clinically work quickly, they often have various side effects and are particularly lacking in protecting target organs; moreover, most hypertensive patients do not control their blood pressure within the ideal range. In long-term clinical application, it is found that chemical antihypertensive drugs often lead to changes in blood biochemical indicators, liver metabolic enzyme disorders, dry cough, heart failure and other side effects; in order to improve the therapeutic effect and eliminate or reduce side effects, a new structure is required Novel compounds with characteristics and novel mechanisms of action

Method used

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Embodiment Construction

[0017] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0018] The present invention relates to the vasodilator effect of the newly synthesized substance 9-octyl-9,10-dihydrochromen[8,7-e][13]oxazin-2(8H)-one (LYF-5).

[0019] The application principle of the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0020] The drug for lowering blood pressure provided by the embodiment of the present invention has the molecular formula: 9-octyl-9,10-dihydrochroman[8,7-e][1,3]oxazine-2(8H) - Ketone; Molecular structural formula is:

[0021]

[0022] The application principle of the present invention will be fu...

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Abstract

The invention belongs to the technical field of medicine and discloses a medicine for reducing blood pressure. The molecular formula of the medicine for reducing blood pressure is 9-octyl-9,10-dihydrobenzopyran [8,7-e][1,3]oxazine-2(8H)-ketone(LYF-5). The LYF-5 has endothelium and non-endothelium dependent vasodilatation effect; the mechanism and the endothelium dependent NO-cGMP signal pathway and the non-endothelium dependent signal pathway mainly inhibit external calcium from flowing inside and inhibit calcium on a sarcoplasmic reticulum from releasing through a VDCC; and the result of theinvention provides a clue for developing the LYF-5 into a new medicine for reducing blood pressure.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a medicine for lowering blood pressure. Background technique [0002] Hypertension is one of the major diseases affecting human health in the world. Its mortality rate and morbidity rate have always been ranked high, and it has become one of the most concerned health problems in the world. In my country, about 200 million people suffer from high blood pressure, among which there are about 2 million new cases of stroke every year, and about 2.5 million people die of cardiovascular diseases. [0003] The principle of treating hypertension is to achieve the purpose of lowering blood pressure and effectively protect target organs, and at the same time reduce and prevent the occurrence of cardiovascular, cerebrovascular and renal complications. At present, drugs through the NO-cGMP signaling pathway are considered to be candidate drugs for preventing and reducing the occurrence of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D498/04A61K31/5383A61P9/12
CPCC07D498/04
Inventor 曹丽华全哲山金昱张文瀚
Owner YANBIAN UNIV
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