A kind of glucofuranosyl triazole compound and its preparation method and fungicide

Abstract

The invention relates to the field of bactericidal compounds, in particular to a furan glucosyl triazole type compound and a preparation and a bactericide thereof. The molecular formula of the furan glucosyl triazole type compound is shown in the following description, wherein R1 is methyl or benzyl, and R2 are phenyl and derivative of the phenyl or ethyl derivatives. Based on structural characteristics of the substrate fructose-6-phosphate and an ISOM catalytic hypothesis mechanism, the inventor adopts a five-membered furan glucose derivative with a similar structure as a basic skeleton, introduces an effective active group triazole structure of pesticides, designs a series of novel furan glucosyl triazole type compounds for the first time, studies the biological activities of the furan glucosyl triazole type compound, examines structure-activity relationships of the furan glucosyl triazole type compound, and lays the foundation for selecting better inhibitors.

Description

technical field The invention relates to the field of bactericidal compounds, in particular to a glucofuranosyl triazole compound, a preparation method thereof and a bactericide. Background technique Agriculture is the foundation of the national economy, a top priority concerning national security, and a long-term challenge and strategic issue facing economic security and social stability. As an indispensable material for agricultural production, pesticides play a key role in resisting pests and diseases. As the country that ranks first in the world in terms of pesticide usage and output, with the entry into the WTO, we can no longer imitate existing foreign varieties. my country's pesticide industry is facing huge challenges. How to develop new pesticides with independent intellectual property rights is a current priority. The most important. The discovery of lead compounds is the first and crucial step in the development of new pesticides. Only when the lead compound is...

AI Technical Summary

Problems solved by technology

However, the existing agricultural insecticides and fungicides targeting the enzymes of the chitin biosynthesis pathway mainly act on chitin synthase or chitinase, and there is no primary and key agent in chitin biosynthesis at home and abroad. Research reports on agricultural fungicidal compounds targeting glucosamine-6-phosphate synthase, only preliminary research in medicine

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