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Preparation method of boric acid PEG modified magnetic graphene nano composite material

A magnetic graphene and nanomaterial technology, applied in the field of nanomaterials, can solve the problems of poor specific identification of Helicobacter pylori, isotope damage to the human body, easy to be ignored, etc., and achieve the effect of good detection effect, good specificity and low cost.

Active Publication Date: 2018-03-13
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, there are two methods used to detect Helicobacter pylori, one is invasive gastroscopy detection, its disadvantage is that the invasive method brings pain to the patient, and some small lesions are easy to be ignored, and the other is non-invasive Breath test, etc., the isotopes used in this method will cause harm to the human body, and the ability to specifically identify Helicobacter pylori is poor

Method used

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  • Preparation method of boric acid PEG modified magnetic graphene nano composite material
  • Preparation method of boric acid PEG modified magnetic graphene nano composite material
  • Preparation method of boric acid PEG modified magnetic graphene nano composite material

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Embodiment 1

[0021] The preparation method of boric acid PEG modified magnetic graphene nanomaterial comprises the steps:

[0022] (1) Dissolve 0.25-0.35mmol dicyclohexylcarbodiimide (DCC) in 10-20mL tetrahydrofuran (THF) to obtain solution A; dissolve 0.15-0.25mmol C 18 —PEG 12 —NH 2 Dissolve 0.15-0.25mmol 4-carboxyphenylboronic acid in another 20-30mL THF, stir at a speed of 650-750r / min under ice bath, then add solution A drop by drop, after solution A is completely added in, stir React overnight to obtain reaction solution B. Dissolve solution B in 0.5-1mL CH 3 OH, and added with CH 2 Cl 2 :CH 3 OH is 100-50:1 eluent packed in the column. The less polar fraction C is collected, which is the desired product. Spin down solution C and dissolve in 1 mL CH 3 OH, solution D was obtained.

[0023] (2) Add 0.14—0.145g of Fe(NO) 3 9H 2 O, 0.100—0.105g Co(NO) 3 ·6H 2 O was added to 15-20mL methanol and sonicated for 1-2h to obtain solution E; 0.8-1.0g of SiO 2 Add another 75-80mL ...

Embodiment 2

[0026] The preparation method of boric acid PEG modified magnetic graphene nanomaterial comprises the steps:

[0027] (1) Dissolve 0.25-0.35mmol dicyclohexylcarbodiimide (DCC) in 10-20mL tetrahydrofuran (THF) to obtain solution A; dissolve 0.15-0.25mmol C 18 —PEG 12 —NH 2Dissolve 0.15-0.25mmol 4-carboxyphenylboronic acid in another 20-30mL THF, stir at a speed of 650-750r / min under ice bath, then add solution A drop by drop, after solution A is completely added in, stir React overnight to obtain reaction solution B. Dissolve solution B in 0.5-1mL CH 3 OH, and added with CH 2 Cl 2 :CH 3 OH is 100-50:1 eluent packed in the column. The less polar fraction C is collected, which is the desired product. Spin down solution C and dissolve in 1 mL CH 3 OH, solution D was obtained.

[0028] (2) Add 0.14—0.145g of Fe(NO) 3 9H 2 O, 0.100—0.105g Co(NO) 3 ·6H 2 O was added to 15-20mL methanol and sonicated for 1-2h to obtain solution E; 0.8-1.0g of SiO 2 Add another 75-80mL o...

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Abstract

The invention discloses a preparation method of a boric acid PEG modified magnetic graphene nano composite material. The prepared boric acid PEG modified magnetic graphene nano composite material hashigh targeting efficiency in helicobacter pylori detection, will not be corroded by gastric acid, achieves a good NMR contrast effect, and has an important meaning for helicobacter pylori diagnosis inclinic.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, in particular to a method for preparing boric acid-modified magnetic graphene composite nanomaterials. Background technique [0002] Nanomaterials have attracted widespread attention due to their potential biomedical applications. Magnetic resonance imaging (MRI) is an imaging method that uses the exchange speed of the contrast agent with the surrounding proton environment under the action of a magnetic field to generate a nuclear magnetic signal that is different from the area where the contrast agent is not injected, and draws the internal structure of the human body. It can reach a micron-level penetration depth, so it has obvious advantages in clinical practice. Magnetic graphene composite material (hereinafter referred to as "MGN" nanomaterial) is an inorganic nanomaterial, and its imaging in the ultraacid gastric environment and its application in the targeted detection of Helicobact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18A61K49/08B82Y15/00B82Y5/00
CPCA61K49/08A61K49/186A61K49/221A61K49/225B82Y5/00B82Y15/00
Inventor 陈卓李云洁谭蔚泓
Owner HUNAN UNIV
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