Purgative composition for cleansing intestinal tract

A intestinal cleansing and composition technology, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, active ingredients of heterocyclic compounds, etc., can solve problems such as inability to use high-risk drugs, permanent kidney disorders, and reduced intestinal cleansing rate , to achieve excellent intestinal cleansing effect, pain relief, and high medication compliance

Inactive Publication Date: 2018-03-09
CTC BIO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is a high-risk drug that cannot be used for patients due to problems such as long-term dialysis due to permanent damage to the kidneys caused by severe acute phosphate nephropathy.
[0006] In addition, in the case of intestinal laxative compositions such as magnesium citrate, sodium picosulfate components, etc., although the patient's medication compliance is improved due to the small dosage, it is different from the existing PEG / electrolyte-containing Controversy that the bowel cleansing rate of the bowel laxative composition is significantly lower than that of the composition itself

Method used

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  • Purgative composition for cleansing intestinal tract
  • Purgative composition for cleansing intestinal tract
  • Purgative composition for cleansing intestinal tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A bowel cleansing laxative composition was prepared with the ingredients shown in Table 1 below. Add 150 g of polyethylene glycol (number average molecular weight: 4800) to an appropriate container, add an appropriate amount of purified water, heat to 60°C to dissolve, and then add 60 mL of sorbitol solution (50% sorbitol), 10 mg Sodium picosulfate and a sweetener were added, and purified water was added in a total volume of 300 mL, followed by complete dissolution at 80°C.

[0037] [Table 1]

[0038] Raw material name

Embodiment 2

[0040] Except using polyethylene glycol with a number average molecular weight of 3000, a laxative composition for bowel cleansing was prepared under the same conditions as in Example 1 above.

Embodiment 3

[0042] A bowel cleansing laxative composition was prepared with the ingredients shown in Table 2 below. Add 130 g of polyethylene glycol (number average molecular weight: 4800) to an appropriate container, add an appropriate amount of purified water, and heat to 60°C to dissolve, then add 90 mL of sorbitol solution (50% sorbitol), 10 mg Sodium picosulfate and a sweetener were added, and purified water was added in a total volume of 300 mL, followed by complete dissolution at 80°C.

[0043] [Table 2]

[0044] Raw material name

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PUM

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Abstract

The present invention relates to a purgative composition for cleansing an intestinal tract and, specifically, to a purgative composition for cleansing an intestinal tract, the composition containing 40-60 g of polyethylene glycol, 10-28 g of sorbitol, and 1-10 mg of sodium picosulfate, on the basis of 100 ml of the composition, or 40-60 g of polyethylene glycol, 10-28 g of sorbitol, and 1-15 mg ofbisacodyl, on the basis of 100 ml of the composition. The purgative composition according to the present invention has higher drug compliance while showing an excellent intestinal tract cleansing rate. In addition, the purgative composition exhibits a sufficient intestinal tract cleansing effect even when taken together with a small amount of water, thereby relieving the suffering that a patientmust take a large amount of medicine when taking a purgative.

Description

technical field [0001] The present invention relates to a laxative composition for intestinal cleansing with excellent intestinal cleansing rate and high medication compliance and an intestinal cleansing method using the same. Background technique [0002] In X-ray examinations, endoscopy, radiography, or bowel cleansing before surgery, it is necessary to empty the interior of the intestine as completely as possible. Therefore, a method of expelling substances inside the intestinal tract to the outside in suspension using water-enemas or hypertonic aqueous solutions containing various salts or the like is commonly used. [0003] In recent years, PEG / electrolyte irrigation compositions consisting of sodium sulfate, potassium chloride, sodium chloride, sodium bicarbonate, and hydrogen-bonded polyethylene glycol (PEG) have been most commonly used. However, since it is necessary to drink about 4 L of the enteric laxative composition solution (Afridi et al., Gastrointest. Endosc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/10A61K31/047A61K31/44A61K31/70A61P1/10
CPCA61K9/08A61K9/10A61K31/047A61K31/44A61K31/70A61K2300/00A61K31/4402A61K31/765A61P1/10A61K9/107
Inventor 全泓烈李凤相金贤一李翰承
Owner CTC BIO INC
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