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Fecal bacterial markers for colorectal cancer

A technology for colon cancer, feces, applied in the field of fecal bacterial markers for colorectal cancer

Active Publication Date: 2018-03-09
THE CHINESE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a simple and affordable method for diagnosing CRC from stool samples is still lacking

Method used

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  • Fecal bacterial markers for colorectal cancer
  • Fecal bacterial markers for colorectal cancer
  • Fecal bacterial markers for colorectal cancer

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0132] The preparation and screening of combinatorial chemical libraries are well known to those skilled in the art. Such combinatorial chemical libraries include, but are not limited to: peptide libraries (see, for example, U.S. Patent No. 5,010,175, Furka, Int. J. Pept. Prot. Res. 37:487-493 (1991) and Houghton et al., Nature 354: 84-88 (1991)), and carbohydrate libraries (see, for example, Liang et al., Science, 274: 1520-1522 (1996) and U.S. Patent No. 5,593,853). Other chemicals used to generate chemical diversity libraries can also be used. Such chemical substances include but are not limited to: peptidomimetics (PCT Publication WO 91 / 19735), encoded peptides (PCT Publication WO 93 / 20242), random biological oligomers (PCT Publication WO 92 / 00091), benzodiazepines (U.S. Patent No. 5,288,514), Diversomers such as hydantoins, benzodiazepines and dipeptides (Hobbs et al., Proc. Nat. Acad. Sci. USA 90: 6909-6913 (1993)), inserts Polypeptides (vinylogouspolypeptides) (Hagihar...

Embodiment

[0167] The following examples are provided for illustration only and not limitation. Those skilled in the art will readily recognize that various non-critical parameters can be changed or modified to produce substantially the same or similar results.

[0168] List of primers and probes used in this study

[0169]

[0170]

[0171] Using Bacteroides clarus, Rossella enterica, Clostridium harthavia, M7 and Fusobacterium nucleatum as stool markers for CRC

[0172] The intestinal microbiota is an important etiological factor in the development of colorectal cancer (CRC). The purpose of this study was to evaluate the utility of newly identified fecal bacterial marker candidates for the diagnosis of CRC through metagenomic sequencing. In this study, by double quantitative PCR (qPCR) analysis, in the stool samples of 439 subjects (203 CRC and 236 healthy subjects) from two independent groups, the abundance of five kinds of bacteria Degree is quantified. By double qPCR, in the stool samp...

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Abstract

Provided is a non-invasive method for diagnosing colorectal cancer in a subject by detecting enrichment or reduction of certain bacterial species. A kit and device useful for such methods are also provided. In addition, a method for reducing the risk of colon cancer by regulating the pertinent bacterial species in human colon is also provided.

Description

[0001] Cross references to related applications [0002] This application claims priority from U.S. Provisional Patent Application No. 62 / 379,635 filed on August 25, 2016, which is incorporated herein in its entirety. Background technique [0003] Colorectal cancer is the third most common cancer in the world, accounting for approximately 10% of all cancer cases diagnosed each year. This is a deadly disease that has a serious impact on human health. For example, during 2012, 1.4 million new cases of colorectal cancer were diagnosed globally and nearly 700,000 deaths were recorded. In developed countries, the incidence of colorectal cancer is significantly higher, with more than 65% of cases detected. Men are more susceptible to this disease than women. [0004] Diagnosing colorectal cancer can be challenging. Although family history may provide useful hints for diagnosis, the vast majority of diseases (greater than 75-95%) occur in people with little or no genetic risk. The symp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/569G01N33/574A61K45/00A61P35/00
CPCA61K45/00C12Q1/689G01N33/56916G01N33/57419G01N33/57484C12Q2600/158C12Q1/6886G01N33/56911G01N2333/33G01N2800/50C12Q1/10A61P35/00C12Q1/6827C12Q2600/112C12Q2600/118C12Q2600/156
Inventor 于君沈祖尧梁巧仪
Owner THE CHINESE UNIVERSITY OF HONG KONG
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