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Pharmaceutical compound preparation for treating staphylococcal pneumonia

A compound preparation, staphylococcus technology, applied in the directions of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as serious complications, and achieve the effects of less sequelae, convenient taking and safe use

Inactive Publication Date: 2018-03-06
CHENGDU LINGXI SHANGPIN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing treatment methods are all through the injection of antibacterial drugs, and then observe the patient's condition, and do further treatment according to the patient's condition. Generally, they are accompanied by relatively serious complications. At present, there is no better way to treat this condition

Method used

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  • Pharmaceutical compound preparation for treating staphylococcal pneumonia
  • Pharmaceutical compound preparation for treating staphylococcal pneumonia
  • Pharmaceutical compound preparation for treating staphylococcal pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The compound oral preparation of this embodiment is prepared by a method known in the pharmaceutical industry, and the specific dosage of each component is shown in Table 1:

[0024] Table 1 The specific dosage of each component

[0025]

[0026]The treatment effect of taking cefazolin and amikacin in combination with two oral medicines at the same time shows that the effect of using cefazolin and amikacin is better than that of a single medicine, thus providing a basis for the development of the two medicines. The compound preparation of rational combination of two kinds of medicines has laid the foundation.

Embodiment 2

[0028] Validation of therapeutic effect in rat model:

[0029] Objective: To observe the effect of different ratios of compound preparations of cefazolin combined with amikacin on DOCA (deoxycorticosterone acetate) rats suffering from staphylococcal pneumonia, so as to explore the therapeutic effect of different doses in the compound .

[0030] Methods: 1200 SD rats, ♂, body weight 180-190g. After resecting the right kidney under aseptic conditions, DOCA 5mg / cattle was administered twice a week, sc, and fed with 1% sodium chloride solution; they were randomly divided into 12 groups, 8 in each group, and the specific grouping and treatment were shown in the table two.

[0031] Table 2 Animal grouping and drug formulation, administration method

[0032]

[0033] Dosing method: the medicine of the compound group was diluted with water into a thin paste, administered by intragastric administration every day, po, qd (orally, once a day); for 5 consecutive weeks.

[0034] Res...

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PUM

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Abstract

The invention discloses a pharmaceutical compound preparation for treating staphylococcal pneumonia. The pharmaceutical compound preparation for treating staphylococcal pneumonia is prepared from thefollowing components in parts by weight: 10 to 300 parts of cefazolin, 10 to 120 parts of amikacin and 10 to 1,600 parts of a medicine carrier, wherein the cefazolin and the amikacin which are used asmedicine compositions are mixed with the medicine carrier to form the compound preparation. The invention provides the cefazolin and amikacin pharmaceutical compound preparation for treating the staphylococcal pneumonia, which is convenient to take and safe to use; the pharmaceutical compound preparation is outstanding in therapeutic effect, reduces complications to an extremely large extent, causes fewer sequel, generally has no side effects, and can help a patient to get well quickly.

Description

technical field [0001] The invention relates to the field of drug compound preparations, in particular to a drug compound preparation for the treatment of staphylococcal pneumonia Background technique [0002] Staphylococcal pneumonia is an acute pulmonary suppurative infection caused by staphylococcus. The condition is serious and often occurs in patients with impaired immune function, such as diabetes, blood diseases (leukemia, lymphoma, aplastic anemia, etc.), AIDS, liver disease, malnutrition, alcoholism, and those who have already suffered from broncho-pulmonary disease. When children suffer from influenza or measles, Staphylococcus bacteria can pass through the respiratory tract and cause pneumonia. If not properly treated, the fatality rate is high. Staphylococcus bacteria in skin infection foci (carbuncle, furuncle, folliculitis, cellulitis, wound infection) can also cause lung infection through blood circulation, and bronchioles are often blocked and accompanied by...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/7036A61P31/04
CPCA61K31/546A61K31/7036A61K2300/00
Inventor 姜迪蛟
Owner CHENGDU LINGXI SHANGPIN TECH CO LTD
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